ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Ambient light regulates sodium channel activity to dynamically control retinal signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Dopaminergic amacrine cells express HCN channels in the developing and adult mouse retina.bioRxiv : the preprint server for biology · 2024Article
- Article
- Inhibitory components of retinal bipolar cell receptive fields are differentially modulated by dopamine D1 receptors.Visual neuroscience · 2020Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Dopamine D1 receptor activation reduces local inner retinal inhibition to light-adapted levels.Journal of neurophysiology · 2019Article
- Expression of GluA2-containing calcium-impermeable AMPA receptors on dopaminergic amacrine cells in the mouse retina.Molecular vision · 2019Article
- Dopamine D1 receptor activation contributes to light-adapted changes in retinal inhibition to rod bipolar cells.Journal of neurophysiology · 2018Article
- Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina.Scientific reports · 2017Article
- M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Dopamine D1 receptor expression is bipolar cell type-specific in the mouse retina.The Journal of comparative neurology · 2016Article
- Multiple cone pathways are involved in photic regulation of retinal dopamine.Scientific reports · 2016Article
- The impact of inhibitory mechanisms in the inner retina on spatial tuning of RGCs.Scientific reports · 2016Article
- Morphological and physiological analysis of type-5 and other bipolar cells in the Mouse Retina.Neuroscience · 2016Article
- Differential encoding of spatial information among retinal on cone bipolar cells.Journal of neurophysiology · 2015Article
- A Novel Retinal Oscillation Mechanism in an Autosomal Dominant Photoreceptor Degeneration Mouse Model.Frontiers in cellular neuroscience · 2015Article
- NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Recurrent axon collaterals of intrinsically photosensitive retinal ganglion cells.Visual neuroscience · 2013Article
- Correlated spontaneous activity persists in adult retina and is suppressed by inhibitory inputs.PloS one · 2013Article
- Identifying cell class specific losses from serially generated electroretinogram components.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The retinal network increases its sensitivity in low-light conditions to detect small visual inputs and decreases its sensitivity in bright-light conditions to prevent saturation. However, the cellular mechanisms that adjust visual signaling in the retinal network are not known. Here, we show that voltage-gated sodium channels in bipolar cells dynamically control retinal light sensitivity. In dim conditions, sodium channels amplified light-evoked synaptic responses mediated by cone pathways. Conversely, in bright conditions, sodium channels were inactivated by dopamine released from amacrine cells, and they did not amplify synaptic inputs, minimizing signal saturation. Our findings demonstrate that bipolar cell sodium channels mediate light adaptation by controlling retinal signaling gain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.