ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
The novel GTPase Rit differentially regulates axonal and dendritic growth.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Who cites it
41 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons.Autonomic neuroscience : basic & clinical · 2023Article
- LZTR1: A promising adaptor of the CUL3 family.Oncology letters · 2021Review
- The molecular functions of RIT1 and its contribution to human disease.The Biochemical journal · 2020Review
- MicroRNAs are Necessary for BMP-7-induced Dendritic Growth in Cultured Rat Sympathetic Neurons.Cellular and molecular neurobiology · 2019Article
- The Ras Superfamily of Small GTPases in Non-neoplastic Cerebral Diseases.Frontiers in molecular neuroscience · 2019Review
- Small GTPase RIT1 in Mouse Retina; Cellular and Functional Analysis.Current eye research · 2018Article
- PAR3-PAR6-atypical PKC polarity complex proteins in neuronal polarization.Cellular and molecular life sciences : CMLS · 2018Review
- RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1.PLoS genetics · 2018Article
- IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade.Scientific reports · 2017Article
- RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis.The Journal of biological chemistry · 2017Article
- BMP7-induced dendritic growth in sympathetic neurons requires p75(NTR) signaling.Developmental neurobiology · 2016Article
- Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis.Scientific reports · 2016Article
- Elevated expression of RIT1 correlates with poor prognosis in endometrial cancer.International journal of clinical and experimental pathology · 2015Article
- Regulatory mechanisms underlying the differential growth of dendrites and axons.Neuroscience bulletin · 2014Review
- Emergence of motor circuit activity.PloS one · 2014Article
- State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.ALTEX · 2014Review
- Rit subfamily small GTPases: regulators in neuronal differentiation and survival.Cellular signalling · 2013Review
- Dendrite complexity of sympathetic neurons is controlled during postnatal development by BMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Putting the Rit in cellular resistance: Rit, p38 MAPK and oxidative stress.Communicative & integrative biology · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The Rit GTPase is widely expressed in developing and adult nervous systems, and our previous data with pheochromocytoma cells implicate Rit signaling in NGF-induced neurite outgrowth. In this study, we investigated a role for Rit in neuronal morphogenesis. Expression of a dominant-negative (dn) Rit mutant in hippocampal neurons inhibited axonal growth but potentiated dendritic growth. Conversely, a constitutively active (ca) Rit mutant promoted axonal growth but inhibited dendritic growth. Dendritogenesis is regulated differently in sympathetic neurons versus hippocampal neurons in that sympathetic neurons require NGF and bone morphogenetic proteins (BMPs) to trigger dendritic growth. Despite these differences, dnRit potentiated and caRit blocked BMP7-induced dendritic growth in sympathetic neurons. Biochemical studies indicated that BMP7 treatments that caused dendritic growth also decreased Rit GTP loading. Additional studies demonstrate that caRit increased extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and pharmacological inhibition of MEK1 (mitogen-activated protein kinase/ERK 1) blocked the axon-promoting and dendrite-inhibiting effects of caRit. These observations suggest that Rit is a convergence point for multiple signaling pathways and it functions to promote axonal growth but inhibit dendritic growth via activation of ERK1/2. Modulation of the activational status of Rit may therefore represent a generalized mechanism across divergent neuronal cell types for regulating axonal versus dendritic growth modes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.