ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Upregulation of polysialylated neural cell adhesion molecule in the dorsal hippocampus after contextual fear conditioning is involved in long-term memory formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 88 citations in OpenAlex.
- Interactions between the Polysialylated Neural Cell Adhesion Molecule and the Transient Receptor Potential Canonical Channels 1, 4, and 5 Induce Entry of CaInternational journal of molecular sciences · 2022Article
- Review
- Acquisition-dependent modulation of hippocampal neural cell adhesion molecules by associative motor learning.Frontiers in neuroanatomy · 2022Article
- Programming effects of peripubertal stress on spatial learning.Neurobiology of stress · 2020Article
- Brain region-dependent alterations in polysialic acid immunoreactivity across the estrous cycle in mice.Hormones and behavior · 2020Article
- Anterior Cingulate Cortex to Ventral Hippocampus Circuit Mediates Contextual Fear Generalization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure.Neurobiology of learning and memory · 2018Article
- Questioning human neurogenesis.Nature · 2018Article
- Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity.Frontiers in nutrition · 2018Article
- Rapid regulation of sialidase activity in response to neural activity and sialic acid removal during memory processing in rat hippocampus.The Journal of biological chemistry · 2017Article
- HDAC7 Ubiquitination by the E3 Ligase CBX4 Is Involved in Contextual Fear Conditioning Memory Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- HPA Axis Interactions with Behavioral Systems.Comprehensive Physiology · 2016Review
- Hippocampal Wnt3a is Necessary and Sufficient for Contextual Fear Memory Acquisition and Consolidation.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Distinct patterns of outcome valuation and amygdala-prefrontal cortex synaptic remodeling in adolescence and adulthood.Frontiers in behavioral neuroscience · 2015Article
- A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats.Neuropharmacology · 2014Article
- Learning improvement after PI3K activation correlates with de novo formation of functional small spines.Frontiers in molecular neuroscience · 2014Article
- NCAM function in the adult brain: lessons from mimetic peptides and therapeutic potential.Neurochemical research · 2013Review
- Article
- Article
- Long-lasting plasticity of hippocampal adult-born neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the hippocampus in pavlovian fear conditioning is controversial. Although lesion and pharmacological inactivation studies have suggested a key role for the dorsal hippocampus in contextual fear conditioning, the involvement of the ventral part is still uncertain. Likewise, the debate is open with regard to the putative implication of each hippocampal subdivision in fear conditioning to a discrete conditioned stimulus. We explored the potential existence of dissociations occurring in the dorsal versus ventral hippocampus at the cellular level while dealing with either contextual or cued fear conditioning and focused in a molecular "signature" linked to structural plasticity, the polysialylated form of the neural cell adhesion molecule (PSA-NCAM). We found an upregulation of PSA-NCAM expression in the dorsal (but not ventral) dentate gyrus at 24 h after contextual (but not tone) fear conditioning. Specific removal of PSA through microinfusion of the enzyme endoneuraminidase-N in the dorsal (but not ventral) hippocampus reduced freezing responses to the conditioned context. Therefore, we present evidence for a specific role of PSA-NCAM in the dorsal hippocampus in the plasticity processes occurring during consolidation of the context representation after "standard" contextual fear conditioning. Interestingly, we also found that exposing animals just to the context induced an activation of PSA-NCAM in both dorsal and ventral dentate gyrus. Altogether, these findings highlighting the distinctive occurrence of these neuroplastic processes in the dorsal hippocampus during the standard contextual fear-conditioning task enlighten the ongoing debate about the involvement of these hippocampal subdivisions in pavlovian fear conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.