ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Botulinum toxin injections reduce associative plasticity in patients with primary dystonia.Movement disorders : official journal of the Movement Disorder Society · 2011Trial
- Focused Modulation of Brain Activity: A Narrative Review.Biomedicines · 2025Review
- Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model.Pharmaceutics · 2023Article
- Developmental refinement of visual callosal inputs to ferret area 17.The Journal of comparative neurology · 2022Article
- Article
- Experimental Intrastriatal Applications of Botulinum Neurotoxin-A: A Review.International journal of molecular sciences · 2018Review
- Review
- Callosal Influence on Visual Receptive Fields Has an Ocular, an Orientation-and Direction Bias.Frontiers in systems neuroscience · 2018Article
- Article
- Reducing GABAScientific reports · 2016Article
- Reorganization of Visual Callosal Connections Following Alterations of Retinal Input and Brain Damage.Frontiers in systems neuroscience · 2016Review
- Visual system plasticity in mammals: the story of monocular enucleation-induced vision loss.Frontiers in systems neuroscience · 2015Review
- Early depolarizing GABA controls critical-period plasticity in the rat visual cortex.Nature neuroscience · 2015Article
- Evidence for metaplasticity in the human visual cortex.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Ocular Manifestations in Infants Resulted from Assisted Reproductive Technology (ART).Journal of family & reproductive health · 2013Article
- Synthetic self-assembling clostridial chimera for modulation of sensory functions.Bioconjugate chemistry · 2013Article
- Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons.PLoS pathogens · 2012Article
- Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism.The EMBO journal · 2012Article
- The role of activity in synaptic degeneration in a protein misfolding disease, prion disease.PloS one · 2012Article
- The corpus callosum and the visual cortex: plasticity is a game for two.Neural plasticity · 2012Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Neural circuits in the cerebral cortex are shaped by experience during "critical periods" early in life. For example, visual cortex is immature at the time of eye opening and gradually develops its functional properties during a sensitive period. Very few reports have addressed the role of intrinsic neural activity in cortical maturation. Here we have exploited the bacterial enzyme botulinum neurotoxin E (BoNT/E) to produce a unilateral, reversible blockade of neural activity in rat visual cortex during the sensitive period. BoNT/E is a highly selective protease that interferes with transmitter release via cleavage of the synaptic protein SNAP-25 (synaptosomal-associated protein of 25 kDa). Unilateral, intracortical injections of BoNT/E were made at the time of eye opening and resulted in the silencing of the treated, but not contralateral, hemisphere for a period of 2 weeks. We found that visual acuity was permanently reduced in the blocked hemisphere, and the critical period for ocular dominance plasticity persisted into adulthood. Unexpectedly, these effects extended equally to the contralateral, uninjected side, demonstrating a fundamental role for interhemispheric connections in cortical maturation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.