Evidence map›Paper›PMID 17458651›Full record

ReviewJournal of anesthesia2007

Volatile anesthetic-induced cardiac preconditioning.

Anna Stadnicka, Jasna Marinovic, Marko Ljubkovic, Martin W Bienengraeber, Zeljko J Bosnjak

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of anesthesia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Dynamic regulation of TASK-1 channels under cellular stress.The journal of physiological sciences : JPS · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
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  8. Article
  9. Review
  10. Review
  11. Cardiac output, at rest and during exercise, before and during myocardial ischemia, reperfusion, and infarction in conscious mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2013
    Article
  12. Article
  13. Myocardial ischemia, reperfusion, and infarction in chronically instrumented, intact, conscious, and unrestrained mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2012
    Article
  14. Article
  15. Article
  16. Article
  17. High doses of ketamine-xylazine anesthesia reduce cardiac ischemia-reperfusion injury in guinea pigs.Journal of the American Association for Laboratory Animal Science : JAALAS · 2011
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna StadnickaDepartment of Anesthesiology, Medical College of Wisconsin, MEB-M4280, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA.
Jasna Marinovic
Marko Ljubkovic
Martin W Bienengraeber
Zeljko J Bosnjak

Funding

Stem Cell CoreP01GM066730 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI DASH, RANJAN K · 2003 to 2019
$23.6M
INTERACTION BETWEEN ANESTHETICS AND CALCIUM ANTAGONISTSR01HL034708 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BOSNJAK, ZELJKO J. · 1986 to 2013
$3.9M
NHLBI NIH HHS HL 034708NIGMS NIH HHS GM066730NIGMS NIH HHS P01 GM066730
6 · The paper itself

Abstract

Pharmacological preconditioning with volatile anesthetics, or anesthetic-induced preconditioning (APC), is a phenomenon whereby a brief exposure to volatile anesthetic agents protects the heart from the potentially fatal consequences of a subsequent prolonged period of myocardial ischemia and reperfusion. Although not completely elucidated, the cellular and molecular mechanisms of APC appear to mimic those of ischemic preconditioning, the most powerful endogenous cardioprotective mechanism. This article reviews recently accumulated evidence underscoring the importance of mitochondria, reactive oxygen species, and K(ATP) channels in cardioprotective signaling by volatile anesthetics. Moreover, the article addresses current concepts and controversies regarding the specific roles of the mitochondrial and the sarcolemmal K(ATP) channels in APC.

Indexed as

Anesthesia, InhalationAnesthetics, InhalationAnimalsHumansIon ChannelsIschemic Preconditioning, MyocardialPotassiumAnesthetics, InhalationIon ChannelsPotassium

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.