ArticleVirchows Archiv : an international journal of pathology2007
Grading invasive ductal carcinoma of the breast: advantages of using automated proliferation index instead of mitotic count.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quantitative Image Analysis of Human Epidermal Growth Factor Receptor 2 Immunohistochemistry for Breast Cancer: Guideline From the College of American Pathologists.Archives of pathology & laboratory medicine · 2019Guideline
- Evaluating the impact of histological vs. nuclear grading on CPS + EG Score for HR + /HER2-early breast cancer.Breast cancer research and treatment · 2025Article
- Deep learning-based breast cancer grading and survival analysis on whole-slide histopathology images.Scientific reports · 2022Article
- Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer.Journal of Cancer · 2021Article
- Quantum dots-based double imaging combined with organic dye imaging to establish an automatic computerized method for cancer Ki67 measurement.Scientific reports · 2016Article
- Quantum dots-based quantitative and in situ multiple imaging on ki67 and cytokeratin to improve ki67 assessment in breast cancer.PloS one · 2015Article
- Semi-automated evaluation of Ki-67 index in invasive ductal carcinoma of the breast.Oncology letters · 2014Article
- Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity.Molecular cancer · 2013Article
- Computer-based image studies on tumor nests mathematical features of breast cancer and their clinical prognostic value.PloS one · 2013Article
- The non-crosslinking fixative RCL2®-CS100 is compatible with both pathology diagnosis and molecular analyses.Pathology oncology research : POR · 2013Article
- The role of the basal stem cell of the human breast in normal development and cancer.Advances in experimental medicine and biology · 2011Review
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Authors and funding
14 authors.
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Abstract
Breast carcinomas are graded according to the "Nottingham modification of the Bloom-Richardson system" (SBR). The system is hindered, however, by lack of precision in assessing all three parameters including nuclear grade, mitosis, and tubular formation, leading to an element of subjectivity. Our objective was to evaluate a new grading system [the nuclear grade plus proliferation (N+P) system] for subjectivity, ease, and better representation of tumor biology. Its components are nuclear grade and automated proliferation index. Invasive ductal carcinomas, consisting of 137 SBR grade I, 247 grade II, and 266 grade III, were re-evaluated by the N+P system. The two systems were compared with each other and correlated with patients' overall survival, tumor size, angiolymphatic invasion, lymph node status, and biomarker status including estrogen receptor, progesterone receptor, p53, epidermal growth factor receptor, BCL-2, and Her-2. Although there was an agreement between the two systems with histologic and prognostic parameters studied, there was 37% disagreement when grading individual tumors. Fifty-three percent of SBR grade II tumors were "down-graded" to N+P grade I, and 7% were "up-graded" to N+P grade III. Distinction among the different histologic grades for overall survival curves was better indicated by the N+P than the SBR system.
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