ArticleInvestigational new drugs2007
Taurolidine: a novel anti-neoplastic agent induces apoptosis of osteosarcoma cell lines.
Article in Investigational new drugs, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer.Scientific reports · 2025Article
- Exploring the effects of taurolidine on tumor weight and microvessel density in a murine model of osteosarcoma.Oncology research · 2024Article
- Dual functionality of the antimicrobial agent taurolidine which demonstrates effective anti-tumor properties in pediatric neuroblastoma.Investigational new drugs · 2020Article
- Taurolidine cooperates with antineoplastic drugs in neuroblastoma cells.Genes & cancer · 2014Article
- Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review).International journal of oncology · 2014Review
- Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma.Journal of experimental & clinical cancer research : CR · 2013Article
- The effects of taurolidine alone and in combination with doxorubicin or carboplatin in canine osteosarcoma in vitro.BMC veterinary research · 2013Article
- Gene expression analysis of cell death induction by taurolidine in different malignant cell lines.BMC cancer · 2010Article
- Comparative analysis of cell death induction by Taurolidine in different malignant human cancer cell lines.Journal of experimental & clinical cancer research : CR · 2010Article
- Characterization and comparison of the properties of sarcoma cell lines in vitro and in vivo.Human cell · 2009Article
- TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma.Journal of experimental & clinical cancer research : CR · 2008Article
- Cytotoxic effects of curcumin on osteosarcoma cell lines.Investigational new drugs · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taurolidine, the active agent of Taurolin, is a broad spectrum anti-biotic that has been used for over 15 years for the treatment of severe surgical infections. Recently, taurolidine has been shown to possess anti-neoplastic properties in vitro and in vivo against a variety of cancers including ovarian, colon and prostate. In this study we assessed the cytotoxic activity of taurolidine against human osteosarcoma (OS) cell lines and normal human bone cells. Treatment with taurolidine inhibited the growth of all ten osteosarcoma cell lines tested and taurolidine was equally potent against cell lines with and without distinct genetic defects (i.e. p53, Rb). Moreover, taurolidine-induced growth inhibition was found to be associated with a dose dependent increase in the number of apoptotic cells and apoptosis was shown to be caspase-dependent. Taurolidine treatment was also found to inhibit adhesion of OS cell lines. Compared to OS cell lines, normal bone cells in primary culture were found to be less sensitive to the cytotoxic and anti-adhesive effects of taurolidine. These data indicate that taurolidine possesses potent anti-neoplastic activity against osteosarcoma cell lines and may have potential as a novel OS chemotherapeutic agent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.