ArticleCurrent microbiology2007
Clinical and environmental Burkholderia strains: biofilm production and intracellular survival.
Article in Current microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Modulatory Effects ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Impact of Quorum Sensing on the Virulence and Survival Traits ofPlants (Basel, Switzerland) · 2024Article
- Evolution of Quorum Sensing inmSystems · 2022Article
- Mapping of the Denitrification Pathway in Burkholderia thailandensis by Genome-Wide Mutant Profiling.Journal of bacteriology · 2020Article
- Positive linkage between bacterial social traits reveals that homogeneous rather than specialised behavioral repertoires prevail in natural Pseudomonas communities.FEMS microbiology ecology · 2020Article
- Loss ofmSphere · 2019Article
- Low spatial structure and selection against secreted virulence factors attenuates pathogenicity in Pseudomonas aeruginosa.The ISME journal · 2018Article
- Article
- Biofilm Formation As a Response to Ecological Competition.PLoS biology · 2015Article
- A metaproteomics approach to elucidate host and pathogen protein expression during catheter-associated urinary tract infections (CAUTIs).Molecular & cellular proteomics : MCP · 2015Article
- Pharmacokinetics and pharmacodynamics of aerosolized antibacterial agents in chronically infected cystic fibrosis patients.Clinical microbiology reviews · 2014Review
- Response of Burkholderia cenocepacia H111 to micro-oxia.PloS one · 2013Article
- The effect of environmental conditions on biofilm formation of Burkholderia pseudomallei clinical isolates.PloS one · 2012Article
- Characterization of the poly-β-1,6-N-acetylglucosamine polysaccharide component of Burkholderia biofilms.Applied and environmental microbiology · 2011Article
- Combination antibiotic susceptibility of biofilm-grown Burkholderia cepacia and Pseudomonas aeruginosa isolated from patients with pulmonary exacerbations of cystic fibrosis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2009Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria belonging to the Burkholderia species are important pulmonary pathogens in cystic fibrosis (CF) patients. Their ability to establish chronic and sometimes fatal infections seems linked to the quorum sensing-regulated expression of virulence factors. We examined 23 Burkholderia isolates, 19 obtained from CF patients and 4 from the environment, to evaluate their ability to form biofilm and to penetrate and replicate inside J774 macrophagic cells. Our results indicate that biofilm formation and intracellular survival are behavioral traits frequently expressed by Burkholderia strains isolated from CF patients. Successive isolates obtained from each of four chronically infected patients yielded bacteria consistently belonging to the same strain but showing increasing ability to replicate intracellularly and to produce biofilm, possibly due to in vivo bacterial microevolution driven by the selective lung environmental conditions. Protection against antimicrobials granted to burkholderiae by the expression of these two virulence factors might account for the frequent failures of antibiotic treatment in CF patients.
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