ArticleHuman genetics2007
Extreme individual marker F(ST )values do not imply population-specific selection in humans: the NRG1 example.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes.Molecular genetics & genomic medicine · 2022Article
- Sequence diversity of the Rh blood group system in Basques.European journal of human genetics : EJHG · 2018Article
- Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews.Genes · 2018Article
- Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa.PLoS genetics · 2014Article
- Article
- Copy number variation analysis in the great apes reveals species-specific patterns of structural variation.Genome research · 2011Article
- Natural selection among Eurasians at genomic regions associated with HIV-1 control.BMC evolutionary biology · 2011Article
- Inter-chromosomal variation in the pattern of human population genetic structure.Human genomics · 2011Article
- Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions.Human genetics · 2011Article
- Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.Genetics · 2009Article
- Adaptive evolution of UGT2B17 copy-number variation.American journal of human genetics · 2008Article
- Worldwide population differentiation at disease-associated SNPs.BMC medical genomics · 2008Article
- Evolutionary analysis of genes of two pathways involved in placental malaria infection.Human genetics · 2008Article
- Adaptive evolution of genes underlying schizophrenia.Proceedings. Biological sciences · 2007Article
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8 authors.
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Abstract
Extreme population differentiation, as measured by the F(ST) value, has been suggested as an indicator of recent population-specific positive selection. Elevated F(ST) values indicating high differentiation between continental groups were previously reported on a linkage disequilibrium region in the Neuregulin 1 gene, a gene which has been associated to schizophrenia. In the present study we show evidence that high F(ST) values may not necessarily imply the action of selection, in particular positive selection, neither globally nor regionally, using the example of the NRG1 gene.
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