Evidence map›Paper›PMID 17457512›Full record

ArticleJournal of human genetics2007

Genetic determination in onset age of wrist fracture.

Donghai Xiong, Wei Wang, Yuan Chen, Hui Jiang, Hong-Wen Deng

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Choice of study phenotype in osteoporosis genetic research.Journal of bone and mineral metabolism · 2009
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Donghai XiongThe Key Laboratory of Biomedical Information Engineering of the Ministry of Education and Institute of Molecular Genetics, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China.
Wei WangThe Key Laboratory of Biomedical Information Engineering of the Ministry of Education and Institute of Molecular Genetics, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China.
Yuan ChenLaboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China.
Hui JiangLaboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, 410081, People's Republic of China.
Hong-Wen DengThe Key Laboratory of Biomedical Information Engineering of the Ministry of Education and Institute of Molecular Genetics, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, People's Republic of China. dengh@umkc.edu.

Funding

ROBUST AND POWERFUL TEST OF CANDIDATE GENES TO BONE MASSR01AR050496 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2004 to 2013
$3.8M
CHARACTERIZATION OF DELETERIOUS GENOMIC MUTATIONSR01GM060402 · NIGMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI DENG, HONG-WEN · 2000 to 2005
$889k
Genetic Basis of Osteoporotic Fractures and Bone MassK01AR002170 · NIAMS · CREIGHTON UNIVERSITY · PI DENG, HONG-WEN · 2001 to 2005
$505k
NIAMS NIH HHS K01 AR02170-01NIAMS NIH HHS R01 AR050496-01NIGMS NIH HHS R01 GM60402-01A1
6 · The paper itself

Abstract

The onset age of fracture may be useful to explore the clinical and genetic heterogeneity of fracture study. In the present study, we investigated the heritability of the onset age of wrist fracture (OAWF) in 30 female full-sib pairs. The phenotypic correlation coefficient of OAWF was 0.309 (P=0.09) for this cohort of female sib pairs, and the narrow-sense heritability (h2) was estimated to be 0.618 (P=0.09). In addition, the h2 derived from the variance component model implemented in SOLAR was 0.722 (P<0.05). This study, for the very first time, suggested that OAWF is under genetic control and thus potentially helps clarify genetic heterogeneity of wrist fracture.

Indexed as

Genetic HeterogeneityGenetic Predisposition to DiseaseAgedAge of OnsetCohort StudiesFemaleFractures, BoneHumansLinear ModelsOsteoporosisWrist Injuries

Identifiers

PMID17457512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.