ArticleAnnals of surgery2007
An evaluation of prognostic factors and tumor staging of resected carcinoma of the esophagus.
Article in Annals of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
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Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Meta-analysis of the influence of a positive circumferential resection margin in oesophageal cancer.BJS open · 2019Pooled it
- Pooled it
- Neoadjuvant chemotherapy with docetaxel, nedaplatin, and fluorouracil for resectable esophageal cancer: A phase II study.Cancer science · 2018Trial
- Influence of Metastatic Status and Number of Removed Lymph Nodes on Survival of Patients With Squamous Esophageal Carcinoma.Medicine · 2015Trial
- Feasibility study of sentinel lymph node biopsy in esophageal cancer with conservative lymphadenectomy.Surgical endoscopy · 2011Trial
- Survival Outcome of Thoraco-Laparoscopic McKeown Esophagectomy Versus Endoscopic Submucosal Dissection for Early-Stage Esophageal Squamous Cell Carcinoma: A Propensity Score-Matched Analysis.Thoracic cancer · 2025Article
- The neoadjuvant esophageal score: a prognostic tool for predicting survival and postoperative complications in esophageal squamous cell carcinoma.Frontiers in immunology · 2025Article
- Left compared with right thoracic approach thoracotomy in esophageal cancer: a retrospective cohort study.Journal of cancer research and clinical oncology · 2023Article
- Histological prognosticators in neoadjuvant naive oesophageal cancer patients.Langenbeck's archives of surgery · 2023Article
- Effect of sex on survival after resection of oesophageal cancer: nationwide cohort study.BJS open · 2022Article
- Long-term Outcomes and Factors Affecting the Survival of Patients with Mucosal Esophageal Squamous Cell Carcinoma.Gut and liver · 2021Article
- Endoscopic resection versus esophagectomy for early esophageal cancer: a meta-analysis.Translational cancer research · 2021Article
- A Promising Esophageal Cancer Prognostic Signature of Ferroptosis-Related LncRNA to Predict Immune Scenery and Immunotherapy Response.International journal of general medicine · 2021Article
- Proposed Modification of the pN2 Classification of the 8th Edition AJCC Staging System for Esophageal Squamous Cell Carcinoma: A Preliminary Study Based on the Chinese Population.Journal of oncology · 2021Article
- Upregulation of PEDF Predicts a Poor Prognosis and Promotes Esophageal Squamous Cell Carcinoma Progression by Modulating the MAPK/ERK Signaling Pathway.Frontiers in oncology · 2021Article
- Comparison of three lymph node staging systems in evaluating the prognosis of patients with pT3 esophageal squamous cell carcinoma.Scientific reports · 2020Article
- Tumour length as an independent prognostic factor in resectable oesophageal carcinoma.Annals of the Royal College of Surgeons of England · 2020Article
- Soft-Tissue Metastases From Esophageal Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- Prognostic impact of examined lymph node count in pT1N0M0 esophageal cancer: A population-based study.Thoracic cancer · 2019Article
- Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate prognostic factors and tumor staging in patients after esophagectomy for cancer. SUMMARY BACKGROUND DATA: Several reports have questioned the appropriateness of the sixth edition of the International Union Against Cancer (UICC) TNM guidelines for staging esophageal cancer. Additional pathologic characteristics, besides the 3 basic facets of anatomic spread (tumor, node, metastases), might also have prognostic value.
methodsAll patients who underwent resection of the esophagus for carcinoma between January 1995 and March 2003 were extracted from a prospective database. Univariate and multivariate analysis was performed to identify prognostic factors for survival. The goodness of fit and accuracy of 3 staging models (UICC-TNM, Korst classification, Rice classification) predicting survival were assessed.
resultsA total of 292 patients (mean age, 63 years) underwent esophagectomy. The 5-year overall survival rate was 29% (median, 21 months). pT-, pN-, pm-stage, and radicality of the resection were independent prognostic factors. Subdivision of T1 tumors into mucosal and submucosal showed significant differences in 5-year survival between both groups: 90% versus 47%, respectively (P = 0.01). Subdivision of pN-stage into 3 groups based on the number of positive nodes (0, 1-2, and >3 nodes positive) or the lymph node ratio (0, 0.01-0.2, and >0.2) also refined staging (P = 0.001 and P < 0.001, respectively). The current subclassification of M1 (M1a and M1b) is not warranted (P = 0.41). The staging model of Rice was more accurate than the UICC-TNM classification in predicting survival.
conclusionThis study supports the view that the current (6th edition) UICC-TNM staging model for esophageal cancer needs to be revised.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.