Trial reportAnnals of surgery2007
Intraoperative blood salvage during liver resection: a randomized controlled trial.
Trial report in Annals of surgery, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PRICE Trial: Phlebotomy Resulting in Controlled Hypovolemia to Prevent Blood Loss in Major Hepatic Resections
PRICE 2: A Phase 3 Randomized Controlled Trial of Phlebotomy Resulting in Controlled Hypovolemia to Prevent Blood Loss in Major Hepatic Resections
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Outcomes After Intraoperative Hypovolemic Phlebotomy in Patients Undergoing Liver Surgery: A Meta-Analysis.World journal of surgery · 2026Pooled it
- Application of cardiovascular interventions to decrease blood loss during hepatectomy: a systematic review and meta-analysis.BMC anesthesiology · 2023Pooled it
- The risk factors of intraoperative conversion during laparoscopic hepatectomy: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2022Pooled it
- Methods to decrease blood loss during liver resection: a network meta-analysis.The Cochrane database of systematic reviews · 2016Pooled it
- Cardiopulmonary interventions to decrease blood loss and blood transfusion requirements for liver resection.The Cochrane database of systematic reviews · 2012Pooled it
- Effects of low central venous pressure during preanhepatic phase on blood loss and liver and renal function in liver transplantation.World journal of surgery · 2010Trial
- Safety and outcomes of hemodilutional autologous transfusion in intermediate- to advanced-level liver resection: a prospective observational study.Surgery today · 2026Article
- Article
- Improvement and development in anatomical hepatectomy for hepatocellular carcinoma.Hepatobiliary surgery and nutrition · 2021Article
- Effect of intraoperative hypovolemic phlebotomy on transfusion and clinical outcomes in patients undergoing hepatectomy: a retrospective cohort study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
- Laparoscopic parenchymal preserving hepatic resections in semiprone position for tumors located in the posterosuperior segments.Langenbeck's archives of surgery · 2016Article
- Intraoperative blood loss in orthotopic liver transplantation: The predictive factors.World journal of gastrointestinal surgery · 2015Review
- [Vascular management in anatomical liver resection].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Review
- How to minimize blood loss during liver surgery in patients with cirrhosis.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2009Article
- Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer.World journal of gastroenterology · 2009Article
- Liver Resection for Hepatocellular Carcinoma: Recent Advances.Journal of clinical and experimental hepatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA randomized controlled trial was conducted to clarify the effectiveness of intraoperative blood salvage in reducing blood loss.
backgroundAlthough reduction of central venous pressure (CVP) is thought to decrease blood loss during liver resection, no consistently effective and safe method for obtaining the desired reduction of CVP has been established.
methodsLiving liver donors scheduled to undergo liver graft procurement were randomly assigned to a blood salvage group, in which a blood volume equal to approximately 0.7% of the patient's body weight was collected before the liver transection, or a control group. The surgeons were blinded to the randomization results. The primary outcome measure was blood loss during liver parenchymal division. A multivariate analysis was also performed.
resultsSeventy-nine donors were allocated intraoperatively to the blood salvage group (n = 40) or the control group (n = 39). The amount of blood loss during liver transection was significantly smaller in the blood salvage group than in the control group (median loss during transection, 140 mL vs. 230 mL, P = 0.034). The CVP at the beginning of the liver parenchymal division was significantly lower in the blood salvage group than in the control group (median, 5 cm H2O vs. 6 cm H2O, P = 0.005). The results of a multivariate analysis revealed that intraoperative blood salvage offered the advantage of reduced blood loss during liver parenchymal division (adjusted OR, 0.31; 95% CI, 0.11-0.85, P = 0.025).
conclusionModest intraoperative blood salvage significantly and safely reduced blood loss during hepatic parenchymal transection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.