ReviewClinical medicine & research2007
An evidence-based update on nonsteroidal anti-inflammatory drugs.
Review in Clinical medicine & research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
190 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Non-steroidal anti-inflammatory drugs (NSAIDs) for trigger finger.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions commonly available during pandemics for heavy menstrual bleeding: an overview of Cochrane Reviews.The Cochrane database of systematic reviews · 2020Pooled it
- Efficacy of proteolytic enzyme bromelain on health outcomes after third molar surgery. Systematic review and meta-analysis of randomized clinical trials.Medicina oral, patologia oral y cirugia bucal · 2019Pooled it
- Chinese specialist consensus on treatment of customary pain in orthopaedics.Orthopaedic surgery · 2010Guideline
- Intravenous Ibuprofen Versus Ketorolac for Perioperative Pain Control in Patients with Morbid Obesity Undergoing Bariatric Surgery: A Randomized Controlled Trial.Obesity surgery · 2025Trial
- Randomized, Placebo-Controlled Pilot Study of Naproxen During Dental Implant Osseointegration.Clinical and experimental dental research · 2025Trial
- Intravenous ibuprofen versus ketorolac for perioperative pain control in open abdominal hysterectomy: a randomized controlled trial.BMC anesthesiology · 2024Trial
- Analgesic effect of oral ibuprofen 400, 600, and 800 mg; paracetamol 500 and 1000 mg; and paracetamol 1000 mg plus 60 mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study.European journal of clinical pharmacology · 2021Trial
- Efficacy of serratiopeptidase after impacted third molar surgery: a randomized controlled clinical trial.BMC oral health · 2021Trial
- Trial
- Etoricoxib improves osteoarthritis pain relief, joint function, and quality of life in the extreme elderly.Bosnian journal of basic medical sciences · 2018Trial
- Trial
- Comparison of the anti-inflammatory effect of dexamethasone and ketorolac in the extractions of third molars.Oral and maxillofacial surgery · 2016Trial
- The PanAM study: a multi-center, double-blinded, randomized, non-inferiority study of paracetamol versus non-steroidal anti-inflammatory drugs in treating acute musculoskeletal trauma.BMC emergency medicine · 2013Trial
- A randomized, double blind, placebo and active comparator controlled pilot study of UP446, a novel dual pathway inhibitor anti-inflammatory agent of botanical origin.Nutrition journal · 2012Trial
- Green synthesis of pyridine-benzofuran hybrids with anti-inflammatory activity alongsideiScience · 2026Article
- Non-Biologic Injections in Sports Medicine.Current reviews in musculoskeletal medicine · 2026Review
- Inflammation in atherosclerosis: Drivers, mechanisms and therapies.Acta pharmaceutica Sinica. B · 2026Review
- Surgeon Perceptions and Experiences with Postoperative Acute Pain Management: A Mixed-Methods Study.Pain and therapy · 2026Article
- Noninvasive Diagnostic Ultrasound-Guided Focused Ultrasound Enables Selective, Reversible Inhibition of Peripheral Nociceptive Fibers and Prevents Acute Pain.bioRxiv : the preprint server for biology · 2026Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs), including both traditional nonselective NSAIDs and the selective cyclooxygenase (COX)-2 inhibitors, are widely used for their anti-inflammatory and analgesic effects. NSAIDs are a necessary choice in pain management because of the integrated role of the COX pathway in the generation of inflammation and in the biochemical recognition of pain. This group of drugs has recently come under scrutiny because of recent focus in the literature on the various adverse effects that can occur when applying NSAIDs. This review will provide an educational update on the current evidence of the efficacy and adverse effects of NSAIDs. It aims to answer the following questions: (1) are there clinically important differences in the efficacy and safety between the different NSAIDs, (2) if there are differences, which are the ones that are more effective and associated with fewer adverse effects, and (3) which are the effective therapeutic approaches that could reduce the adverse effects of NSAIDs. Finally, an algorithm is proposed which delineates a general decision-making tree to select the most appropriate analgesic for an individual patient based on the evidence reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.