ArticleMolecular endocrinology (Baltimore, Md.)2007
Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha.
Article in Molecular endocrinology (Baltimore, Md.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 93 citations in OpenAlex.
- A role for the transcriptional coregulator RIP140 in the control of muscle endurance fitness.JCI insight · 2025Article
- SENP2 regulates UCP1-dependent thermogenesis in brown adipocytes via deSUMOylation of ERRα.Experimental & molecular medicine · 2025Article
- RIP140 deficiency enhances cardiac fuel metabolism and protects mice from heart failure.The Journal of clinical investigation · 2023Article
- Nuclear receptors in the kidney during health and disease.Molecular aspects of medicine · 2021Review
- Pharmacological modulation of RORα controls fat browning, adaptive thermogenesis, and body weight in mice.American journal of physiology. Endocrinology and metabolism · 2021Article
- Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator-activated receptor α.The Journal of biological chemistry · 2020Article
- FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.Nature communications · 2020Article
- Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases.International journal of molecular sciences · 2020Review
- The Krüppel-Like Factors and Control of Energy Homeostasis.Endocrine reviews · 2019Review
- ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease.Frontiers in endocrinology · 2019Review
- Estrogen-Related Receptors Mediate the Adaptive Response of Brown Adipose Tissue to Adrenergic Stimulation.iScience · 2018Article
- The nuclear retinoid-related orphan receptor RORα controls circadian thermogenic programming in white fat depots.Physiological reports · 2018Article
- Involvement of receptor-interacting protein 140 in palmitate-stimulated macrophage infiltration of pancreatic beta cells.Experimental and therapeutic medicine · 2017Article
- DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.Cell discovery · 2017Article
- Complementary Roles of Estrogen-Related Receptors in Brown Adipocyte Thermogenic Function.Endocrinology · 2016Article
- FADD is a key regulator of lipid metabolism.EMBO molecular medicine · 2016Article
- Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.The Journal of clinical investigation · 2016Article
- Oral administration of Lactobacillus plantarum 299v modulates gene expression in the ileum of pigs: prediction of crosstalk between intestinal immune cells and sub-mucosal adipocytes.Genes & nutrition · 2015Article
- Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions.PPAR research · 2015Review
- Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice.Biology of sex differences · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Expression of uncoupling protein 1 (Ucp1) mRNA is elevated in differentiated adipocytes derived from brown or white adipose tissue devoid of the nuclear receptor corepressor receptor interacting protein 140 (RIP140). Increased expression is mediated in part by the recruitment of peroxisome proliferator activated receptors alpha and gamma, together with estrogen-related receptor alpha, which functions through a novel binding site on the Ucp1 enhancer. This demonstrates that regulation of Ucp1 expression in the absence of RIP140 involves derepression of at least three different nuclear receptors. The ability to increase expression of Ucp1 by beta-adrenergic signaling is independent of RIP140, as shown by the action of the beta(3)-adrenergic agonist CL 316,243 to stimulate expression in both brown and white adipocytes in the presence and absence of the corepressor. Therefore, the expression of this metabolic uncoupling protein in adipose cells is regulated by inhibition as well as activation of distinct signaling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.