ReviewProtein science : a publication of the Protein Society2007
The FliK protein and flagellar hook-length control.
Review in Protein science : a publication of the Protein Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Identification and Expression of Immunogenic Mimotopes ofVaccines · 2026Article
- The impact of the flagellar protein genemSphere · 2025Article
- Design of a multi-epitope-based vaccine candidate against Bovine Genital Campylobacteriosis using a reverse vaccinology approach.BMC veterinary research · 2024Article
- Predictive modeling of antibiotic eradication therapy success for new-onset Pseudomonas aeruginosa pulmonary infections in children with cystic fibrosis.PLoS computational biology · 2023Article
- Dynamic stiffening of the flagellar hook.Nature communications · 2022Article
- Proteome and Physiological Characterization of Halotolerant Nodule Endophytes: The Case ofMicroorganisms · 2022Article
- Genome-Wide Association Study Reveals Host Factors Affecting Conjugation inMicroorganisms · 2022Article
- The global regulators ArcA and CytR collaboratively modulate Vibrio cholerae motility.BMC microbiology · 2022Article
- Article
- The Polar Flagellar Transcriptional Regulatory Network inJournal of bacteriology · 2021Article
- Niche partitioning in the Rimicaris exoculata holobiont: the case of the first symbiotic Zetaproteobacteria.Microbiome · 2021Article
- Detecting qualitative changes in biological systems.Scientific reports · 2020Article
- The flagella of 'Candidatus Liberibacter asiaticus' and its movement in planta.Molecular plant pathology · 2020Article
- In vivo structure of the Legionella type II secretion system by electron cryotomography.Nature microbiology · 2019Article
- Genomic analyses of two Alteromonas stellipolaris strains reveal traits with potential biotechnological applications.Scientific reports · 2019Article
- Species-dependent hydrodynamics of flagellum-tethered bacteria in early biofilm development.Journal of the Royal Society, Interface · 2016Article
- Type Three Secretion System in Attaching and Effacing Pathogens.Frontiers in cellular and infection microbiology · 2016Review
- The role of probiotics in the inhibition of Campylobacter jejuni colonization and virulence attenuation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Review
- Differential single nucleotide polymorphism-based analysis of an outbreak caused by Salmonella enterica serovar Manhattan reveals epidemiological details missed by standard pulsed-field gel electrophoresis.Journal of clinical microbiology · 2015Article
- Identification and characterization of a novel flagellum-dependent Salmonella-infecting bacteriophage, iEPS5.Applied and environmental microbiology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterial flagellum is a highly complex prokaryotic organelle. It is the motor that drives bacterial motility, and despite the large amount of energy required to make and operate flagella, motile organisms have a strong adaptive advantage. Flagellar biogenesis is both complex and highly coordinated and it typically involves at least three two-component systems. Part of the flagellum is a type III secretion system, and it is via this structure that flagellar components are exported. The assembly of a flagellum occurs in a number of stages, and the "checkpoint control" protein FliK functions in this process by detecting when the flagellar hook substructure has reached its optimal length. FliK then terminates hook export and assembly and transmits a signal to begin filament export, the final stage in flagellar biosynthesis. As yet the exact mechanism of how FliK achieves this is not known. Here we review what is known of the FliK protein and discuss the evidence for and against the various hypotheses that have been proposed in recent years to explain how FliK controls hook length, FliK as a molecular ruler, the measuring cup theory, the role of the FliK N terminus, the infrequent molecular ruler theory, and the molecular clock theory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.