ArticleBlood2007
Multiple prethymic defects underlie age-related loss of T progenitor competence.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T-Cell Immunity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Clonal Analyses Reveal the Impact of Hematopoietic Stem and Progenitor Cell Aging on T Cell Development.Aging cell · 2026Article
- Endogenous thymic regeneration: restoring T cell production following injury.Nature reviews. Immunology · 2025Review
- Article
- Review
- Age-related thymic involution: Mechanisms and functional impact.Aging cell · 2022Review
- T cell regeneration after immunological injury.Nature reviews. Immunology · 2021Review
- FLT3 ligand regulates thymic precursor cells and hematopoietic stem cells through interactions with CXCR4 and the marrow niche.Experimental hematology · 2017Article
- Genetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell Function.Stem cells international · 2016Review
- Circulating Hematopoietic Stem and Progenitor Cells in Aging Atomic Bomb Survivors.Radiation research · 2016Article
- Age-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Young, proliferative thymic epithelial cells engraft and function in aging thymuses.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Effect of aged bone marrow microenvironment on mesenchymal stem cell migration.Age (Dordrecht, Netherlands) · 2015Article
- Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue.Immunity & ageing : I & A · 2014Article
- Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- T-cell reconstitution after allogeneic stem cell transplantation: assessment by measurement of the sjTREC/βTREC ratio and thymic naive T cells.Haematologica · 2013Article
- Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Causes, consequences, and reversal of immune system aging.The Journal of clinical investigation · 2013Review
- Article
- A simple model system enabling human CD34(+) cells to undertake differentiation towards T cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Aging in mice and humans is characterized by declining T-lymphocyte production in the thymus, yet it is unclear whether aging impacts the T-lineage potential of hematopoietic progenitors. Although alterations in the lymphoid progenitor content of aged mouse bone marrow (BM) have been described, irradiation-reconstitution experiments have failed to reveal defects in T-lineage potential of BM hematopoietic progenitors or purified hematopoietic stem cells (HSCs) from aged mice. Here, we assessed T-progenitor potential in unmanipulated recipient mice without conditioning irradiation. T-progenitor potential was reduced in aged BM compared with young BM, and this reduction was apparent at the earliest stages of intrathymic differentiation. Further, enriched populations of aged HSCs or multipotent progenitors (MPPs) gave rise to fewer T-lineage cells than their young counterparts. Whereas the T-precursor frequency within the MPP pool was unchanged, there was a 4-fold decline in T-precursor frequency within the HSC pool. In addition, among the T-competent HSC clones, there were fewer highly proliferative clones in the aged HSC pool than in the young HSC pool. These results identify T-compromised aged HSCs and define the nature and cellular sites of prethymic, age-related defects in T-lineage differentiation potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.