ArticlePLoS medicine2007
Why most published research findings are false: problems in the analysis.
Article in PLoS medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Transcriptional signatures of brain aging and Alzheimer's disease: What are our rodent models telling us?Behavioural brain research · 2017Pooled it
- A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.Environmental health : a global access science source · 2016Pooled it
- The horizontal ladder test (HLT) protocol: a novel, optimized, and reliable means of assessing motor coordination inFrontiers in behavioral neuroscience · 2024Article
- The Horizontal Ladder Test (HLT) protocol: A novel, optimized, and reliable means of assessing motor coordination inbioRxiv : the preprint server for biology · 2023Article
- Reconsidering evidence-based management of endometriosis.Facts, views & vision in ObGyn · 2022Article
- Article
- Microbial involvement in Alzheimer disease development and progression.Molecular neurodegeneration · 2020Review
- Statistical significance: p value, 0.05 threshold, and applications to radiomics-reasons for a conservative approach.European radiology experimental · 2020Article
- Comparative effectiveness of secukinumab and etanercept in biologic-naïve patients with psoriatic arthritis assessed by matching-adjusted indirect comparison.European journal of rheumatology · 2019Article
- A theory and methodology to quantify knowledge.Royal Society open science · 2019Article
- Comparative effectiveness of secukinumab and adalimumab in ankylosing spondylitis as assessed by matching-adjusted indirect comparison.European journal of rheumatology · 2018Article
- Ten quick tips for getting the most scientific value out of numerical data.PLoS computational biology · 2018Article
- The replication crisis in epidemiology: snowball, snow job, or winter solstice?Current epidemiology reports · 2018Article
- Secukinumab Versus Adalimumab for Psoriatic Arthritis: Comparative Effectiveness up to 48 Weeks Using a Matching-Adjusted Indirect Comparison.Rheumatology and therapy · 2018Article
- HomeopathicJournal of traditional and complementary medicine · 2018Article
- Cautionary Note on Using Cross-Validation for Molecular Classification.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
- Limitation of number of strains and persistence of false positive loci in QTL mapping using recombinant inbred strains.PloS one · 2014Article
- Genomics and successful aging: grounds for renewed optimism?The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?Current gene therapy · 2009Review
- Why most published research findings are false: author's reply to Goodman and Greenland.PLoS medicine · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.