ArticleFolia microbiologica2006
Activity of translation system and abundance of tmRNA during development of Streptomyces aureofaciens producing tetracycline.
Article in Folia microbiologica, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Defining the networks that connect RNase III and RNase J-mediated regulation of primary and specialized metabolism inJournal of bacteriology · 2025Article
- 6S-Like scr3559 RNA Affects Development and Antibiotic Production inMicroorganisms · 2021Article
- Secondary Metabolites Produced during the Germination ofFrontiers in microbiology · 2017Article
- A Waking Review: Old and Novel Insights into the Spore Germination inFrontiers in microbiology · 2017Review
- Expression of tmRNA in mycobacteria is increased by antimicrobial agents that target the ribosome.FEMS microbiology letters · 2011Article
- Transfer-messenger RNA controls the translation of cell-cycle and stress proteins in Streptomyces.EMBO reports · 2010Article
- tmRNA of Streptomyces collinus and Streptomyces griseus during the growth and in the presence of antibiotics.Microbial biotechnology · 2009Article
- tmRNA abundance in Streptomyces aureofaciens, S. griseus and S. collinus under stress-inducing conditions.Folia microbiologica · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transition from exponential phase of growth to stationary phase in Streptomyces aureofaciens is characterized by a decrease in the rate of translation and induction of tetracycline (Ttc) biosynthesis. In exponential phase, no significant changes were found in the activity of ribosomes at binding of ternary complex Phe-tRNA.EF-Tu.GTP to the A-site on ribosomes. Overexpression of Ttc in stationary phase is accompanied by a decrease in the binding of the ternary complex Phe-tRNA.EF-Tu.GTP to the A-site of ribosome and a formation of an aggregate with Ttc by part of the ribosomes. Antibiotics that cause ribosome to stall or pause could increase the requirement for tmRNA in the process called trans-translation. We found differences in the level of tmRNA during the development of S. aureofaciens. Subinhibitory concentrations of Ttc, streptomycin and chloramphenicol induced an increase in the tmRNA level in cells from the exponential phase of growth. In vitro trans-translation system of S. aureofaciens was sensitive to Ttc at a concentration of > 15 micromol/L; the trans-translation system can thus be considered to contribute to resistance against Ttc produced only at sublethal concentrations. These experiments suggest that the main role of the rising tmRNA level at the beginning of the Ttc production is connected with ribosome rescue.
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