ArticleInternational journal of cancer2007
Induction of Smad1 by MT1-MMP contributes to tumor growth.
Article in International journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Unravelling the Network of Nuclear Matrix Metalloproteinases for Targeted Drug Design.Biology · 2020Review
- Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment.Cell death discovery · 2017Review
- Immunoexpression of metalloproteinases 2 and 14 and TIMP-2 inhibitor in main types of primary gastric carcinomas and lymph node metastasis.Pathology oncology research : POR · 2015Article
- Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-β signaling.The Journal of biological chemistry · 2014Article
- The novel lupus antigen related protein acheron enhances the development of human breast cancer.International journal of cancer · 2012Article
- Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression.The Biochemical journal · 2012Review
- RNAi-mediated gene silencing in tumour tissue using replication-competent retroviral vectors.Gene therapy · 2011Article
- MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling.Molecular cancer research : MCR · 2011Article
- Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system.Neural development · 2010Article
- MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3.British journal of cancer · 2008Article
- Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase.Molecular biology of the cell · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
MT1-MMP is a key integral membrane protease, which regulates tumor growth by cleaving extracellular matrix components, activating growth factors and receptors, and consequently, triggering downstream signals. To study what genes or pathways are mediated by endogenous MT1-MMP during tumor growth in vivo, we stably suppressed endogenous MT1-MMP in human tumor cells using RNA interference (RNAi). Tumor growth was significantly reduced in tumors derived from MT1-MMP-suppressed cells relative to control cells; the effect was rescued in cells engineered to re-express MT1-MMP expression. Gene expression profiling of cultured and tumor-derived cells by DNA microarray and real-time RT-PCR revealed that Smad1 expression was upregulated in MT1-MMP-expressing cells and rapidly growing tumors; this was confirmed in 4 additional tumor cell lines. Furthermore, tumor growth of MT1-MMP-expressing cells was reduced when Smad1 was suppressed by RNAi. We also found that the active form, but not the latent form, of TGF-beta was capable in promoting Smad1 expression and 3D cell proliferation in MT1-MMP-suppressed cells. In addition, a dominant-negative form of the TGF-beta Type II receptor reduced Smad1 expression in MT1-MMP-expressing cells. Thus, we propose that MT1-MMP functions, in part, to promote tumor growth by inducing the expression of Smad1 via TGF-beta signaling.
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