Trial reportMicrocirculation (New York, N.Y. : 1994)
Noninvasive measure of microvascular nitric oxide function in humans using very low-frequency cutaneous laser Doppler flow spectra.
Trial report in Microcirculation (New York, N.Y. : 1994). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 44 citations in OpenAlex.
- The Emerging Role of Endothelial Ion Channels in the Control of Human Microcirculation.International journal of molecular sciences · 2026Review
- Prediction of Microvascular Adaptation to Hypoxia Based on Myogenic Microcirculation Oscillations.Sensors (Basel, Switzerland) · 2025Article
- The phase coherence of the neurovascular unit is reduced in Huntington's disease.Brain communications · 2024Article
- Review
- Vasomotion analysis of speed resolved perfusion, oxygen saturation, red blood cell tissue fraction, and vessel diameter: Novel microvascular perspectives.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022Article
- Spectral Analysis of Muscle Hemodynamic Responses in Post-Exercise Recovery Based on Near-Infrared Spectroscopy.Sensors (Basel, Switzerland) · 2021Article
- Article
- The contribution of sensory nerves to cutaneous vasodilatation of the forearm and leg to local skin heating.European journal of applied physiology · 2015Article
- Evolution of cardiorespiratory interactions with age.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2013Article
- Nonlinear dynamics of cardiovascular ageing.Physics reports · 2010Article
- Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment.Microvascular research · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWhile higher frequency oscillations (0.021-0.6 Hz) in cutaneous blood flow measured by laser Doppler flowmetry (LDF) relate to oscillations in blood pressure and sympathetic nerve activity, very low-frequency oscillations (VLF, 0.0095-0.021 Hz) do not. The authors investigated whether VLF LDF power is nitric oxide (NO) specific.
methodsLDF combined with intradermal microdialysis was used in the calves of 22 healthy volunteers aged 19-27 years. LDF power spectral analysis was performed by windowed fast Fourier transform. The authors tested whether the NO synthesis inhibitor nitro-l-arginine (NLA) produced selective decreases in VLF power before and after stimulation with acetylcholine.
resultsNLA alone did not alter total power but selectively reduced VLF power by approximately 50%. LDF and spectral power increased markedly across all spectra with acetylcholine. This increase was blunted by NLA, which selectively reduced VLF power by approximately 50%.
conclusionsThe data suggest that VLF oscillations in the laser Doppler signal are NO dependent, increase with cholinergic stimulation, and have potential as a noninvasive marker for NO-dependent microvascular reactivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.