Evidence map›Paper›PMID 17453146›Full record

ArticleJournal of neuro-oncology2007

Loss of heterozygosity studies in extracranial metastatic meningiomas.

Caroline Regna Gladin, Ettore Salsano, Francesca Menghi, Marina Grisoli, Francesco Ghielmetti, Ida Milanesi, Bianca Pollo, Stefano Brock, Alberto Cusin, Ludovico Minati and 2 more

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In one paragraph

Article in Journal of neuro-oncology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Caroline Regna GladinDepartment of Experimental Neurology and Diagnostics, Fondazione IRCCS Istituto Neurologico Besta, Milano, Italy.
Ettore Salsano
Francesca Menghi
Marina Grisoli
Francesco Ghielmetti
Ida Milanesi
Bianca Pollo
Stefano Brock
Alberto Cusin
Ludovico Minati
Gaetano Finocchiaro
Maria Grazia Bruzzone
Fondazione IRCCS Istituto Neurologico Carlo Besta · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although most meningiomas are slow-growing tumours associated with favourable prognosis, they often present local recurrence after surgical treatment; by contrast, extracranial metastatic meningiomas are rare, occurring in less than 1% of the cases. Risk factors for distal spread remain largely unknown. We report three cases with lung or bone metastases from intracranial recurrent meningiomas. Loss of heterozygosity (LOH) analysis on 1p, 9p, 10q, 14q, and 22q was conducted in available primary, recurrent and metastatic lesions, showing the same LOH pattern in the distal metastases and in the intracranial meningioma. LOH at 1p, 14q and 9p, known to be associated with increased aggressiveness, were found. The results highlight the potential clinical relevance of integrating histopathological studies with molecular genetic analysis in the follow-up of patients with different types of meningiomas.

Indexed as

AdultBone NeoplasmsBrainChromosomesDNA, NeoplasmHumansLoss of HeterozygosityLung NeoplasmsMaleMeningiomaMiddle AgedNeoplasm MetastasisReverse Transcriptase Polymerase Chain ReactionTomography, X-Ray ComputedDNA, Neoplasm

Identifiers

PMID17453146
OpenAlexW2162429918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.