ArticleBritish journal of cancer2007
Number of siblings and the risk of solid tumours: a nation-wide study.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Impact of maternal reproductive factors on cancer risks of offspring: A systematic review and meta-analysis of cohort studies.PloS one · 2020Pooled it
- A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the mother.International journal of epidemiology · 2009Pooled it
- Postnatal determinants of testicular germ cell tumor by histological subtypes: The EPSAM1 and EPSAM2 studies.International journal of cancer · 2026Article
- Familial testicular germ cell tumors in two brothers.IJU case reports · 2020Article
- Interactions of Consanguinity and Number of Siblings with Childhood Acute Lymphoblastic Leukemia.BioMed research international · 2020Article
- Birth order and mortality: a population-based cohort study.Demography · 2015Article
- Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case-control study.Cancer epidemiology · 2011Article
- Influence of family size and birth order on risk of cancer: a population-based study.BMC cancer · 2011Article
- Birth order and risk of non-hodgkin lymphoma--true association or bias?American journal of epidemiology · 2010Article
- The association between birth order, sibship size and glioma development in adulthood.International journal of cancer · 2010Article
- Etiologic factors in testicular germ-cell tumors.Future oncology (London, England) · 2009Review
- Association between number of siblings and cause-specific mortality in the Glasgow alumni cohort study.European journal of epidemiology · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analysed the effects of number of siblings on the risk of solid tumours using the Swedish Family-Cancer Database, including population-based information on over 11 million individuals and more than 178,000 cancer patients diagnosed between 1958 and 2004. Incidence rate ratios (RRs), estimated by Poisson regression models, were adjusted for age, sex, birth cohort, area of residence and socioeconomic status. Having eight or more siblings vs none increased the risk of stomach cancer (RR=1.83, 95% confidence interval (CI), 1.44-2.34). Anal cancer diagnosed before age 40 showed the strongest association with the total siblings (RR=3.27, 95% CI, 2.04-5.26 for five or more siblings vs none). Endometrial (RR=0.76, 95% CI, 0.70-0.82), testicular (RR=0.71, 95% CI, 0.62-0.82), skin cancer (RR=0.82, 95% CI, 0.69-0.97) and melanoma (RR=0.72, 95% CI, 0.65-0.79) showed strong decreased risks for five or more siblings vs none. Prostate cancer risk for those with five or more older siblings vs none was 1.38 (95% CI, 1.23-1.55). Having five or more younger siblings was most strongly associated with stomach cancer (RR=1.59, 95% CI, 1.29-1.95) and melanoma (RR=0.68, 95% CI, 0.59-0.79). We conclude that sibship characteristics are strong correlates of cancer risk at several sites; plausible interpretations include socioeconomic status.
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