ArticleBritish journal of cancer2007
Human papillomavirus in high- and low-risk areas of oesophageal squamous cell carcinoma in China.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- HPV prevalence in esophageal cancer: an updated systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Prevalence of HPV Infection Among Chinese Males With HPV-Related Diseases: A Systematic Review and Meta-Analysis.Journal of medical virology · 2025Pooled it
- Mucosal alpha-papillomaviruses are not associated with esophageal squamous cell carcinomas: Lack of mechanistic evidence from South Africa, China and Iran and from a world-wide meta-analysis.International journal of cancer · 2016Pooled it
- Association between human papillomavirus (HPV) and oesophageal squamous cell carcinoma: a meta-analysis.Epidemiology and infection · 2014Pooled it
- Review
- Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism.World journal of gastroenterology · 2020Article
- CircRNA_100876 Is Upregulated in Gastric Cancer (GC) and Promotes the GC Cells' Growth, Migration and Invasion via miR-665/YAP1 Signaling.Frontiers in genetics · 2020Article
- Prevalence of human papillomavirus genotypes in cervical cancer in Maiduguri, Nigeria.The Pan African medical journal · 2019Article
- The bidirectional association between oral cancer and esophageal cancer: A population-based study in Taiwan over a 28-year period.Oncotarget · 2017Article
- Article
- Human papillomavirus and gastrointestinal cancer: A review.World journal of gastroenterology · 2016Review
- Human papillomavirus tumor infection in esophageal squamous cell carcinoma.Journal of gastrointestinal oncology · 2015Review
- Prevalence of human papillomavirus in esophageal carcinoma in Tangshan, China.World journal of gastroenterology · 2015Article
- Human papillomavirus 16 infection predicts poor outcome in patients with esophageal squamous cell carcinoma.OncoTargets and therapy · 2015Article
- Type-specific detection of human papillomaviruses in Kazakh esophageal squamous cell carcinoma by genotyping both E6 and L1 genes with MALDI-TOF mass spectrometry.International journal of clinical and experimental pathology · 2015Article
- High-risk and low-risk human papillomavirus in esophageal squamous cell carcinoma at Mazandaran, Northern Iran.Pathology oncology research : POR · 2013Article
- The role of inflammation in HPV infection of the Oesophagus.BMC cancer · 2013Article
- Incidence of human papilloma virus in esophageal squamous cell carcinoma in patients from the Lublin region.World journal of gastroenterology · 2012Article
- The prevalence of human papilloma virus in esophageal squamous cell carcinoma.Iranian journal of medical sciences · 2012Article
- Human papillomavirus in upper digestive tract tumors from three countries.World journal of gastroenterology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the potential roles of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (ESCC) development, we examined the presence of HPV DNA in paraffin-embedded ESCC tissues collected from two areas with different ESCC incidence rates in China, that is, Gansu (n=26) and Shandong (n=33), using PCR with SPF10 primers, or PCR with GP5+/GP6+ primers combined with Southern blot hybridisation. HPV genotype was determined by the INNO-LiPA HPV genotyping kit. HPV DNA was detected in 17 cases (65%) in Gansu, where ESCC incidence is much higher than in Shandong, where HPV was positive in two samples (6%). HPV genotypes 16 and 18 were detected in 79 and 16% of HPV-positive samples, respectively. Real-time PCR analysis suggested the presence of integrated form of HPV DNA in all the HPV-16-positive samples, but its viral load was estimated to be only <1-2 copies cell(-1). We could not detect HPV 16/18 E6 protein expression by immunostaining in any of the HPV-16-positive samples. Neither p16(INK4a) nor p53 expression was related to HPV presence in ESCCs. Further studies seem warranted to examine the possible aetiological roles of HPV in ESCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.