ArticleOncogene2007
Roles of BCCIP in chromosome stability and cytokinesis.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
- Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes.Open research Europe · 2023Article
- Overexpression of BCCIP predicts an unfavorable prognosis and promotes the proliferation and migration of lung adenocarcinoma.Thoracic cancer · 2021Article
- Requirement of Bccip for the Regeneration of Intestinal Progenitors.The American journal of pathology · 2021Article
- BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis.Nucleic acids research · 2020Article
- Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice.The American journal of pathology · 2020Article
- Identification of microRNA signature in the progression of gestational trophoblastic disease.Cell death & disease · 2018Article
- Roles of BCCIP deficiency in mammary tumorigenesis.Breast cancer research : BCR · 2017Article
- BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.Journal of molecular cell biology · 2017Article
- High Expression of BCCIP β Can Promote Proliferation of Esophageal Squamous Cell Carcinoma.Digestive diseases and sciences · 2017Article
- Celecoxib enhances the radiosensitivity of HCT116 cells in a COX-2 independent manner by up-regulating BCCIP.American journal of translational research · 2017Article
- Expression pattern of BCCIP in hepatocellular carcinoma is correlated with poor prognosis and enhanced cell proliferation.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells.Protein & cell · 2016Article
- A cancer-associated mutation inactivates a region of the high-mobility group protein HMG20b essential for cytokinesis.Cell cycle (Georgetown, Tex.) · 2014Article
- BCCIP suppresses tumor initiation but is required for tumor progression.Cancer research · 2013Article
- Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation.Cell cycle (Georgetown, Tex.) · 2013Article
- The role of AEG-1/MTDH/LYRIC in the pathogenesis of central nervous system disease.Advances in cancer research · 2013Review
- Article
- Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes.PLoS genetics · 2011Article
- Article
- Astrocyte elevated gene-1 and breast cancer (Review).Oncology letters · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The BRCA2 gene is involved in recombinational DNA repair and cytokinesis. BRCA2 defects are associated with chromosomal abnormalities, which is a hallmark of genomic instability that contributes to tumorigenesis. Here, we show that downregulation of a BRCA2 interacting protein (BCCIP) in HT1080 cells leads to chromosomal polyploidization, centrosome amplification and abnormal mitotic spindle formation. The BCCIP knockdown cells can enter mitosis and retain spindle checkpoint, but fail to complete cytokinesis. Our data suggest an essential role of BCCIP in the maintenance of genomic integrity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.