ArticleOncogene2007
Gadd45a regulates beta-catenin distribution and maintains cell-cell adhesion/contact.
Article in Oncogene, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- GADD45G Interacts with E-cadherin to Suppress the Migration and Invasion of Esophageal Squamous Cell Carcinoma.Digestive diseases and sciences · 2020Article
- Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC.Nature communications · 2018Article
- MiR-148a increases glioma cell migration and invasion by downregulating GADD45A in human gliomas with IDH1 R132H mutations.Oncotarget · 2017Article
- Article
- Directional migration and transcriptional analysis of oligodendrocyte precursors subjected to stimulation of electrical signal.American journal of physiology. Cell physiology · 2015Article
- Aurora-A enhances malignant development of esophageal squamous cell carcinoma (ESCC) by phosphorylating β-catenin.Molecular oncology · 2015Article
- Fucoxanthin: A Promising Medicinal and Nutritional Ingredient.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.The Journal of biological chemistry · 2014Article
- DNA damage response genes and the development of cancer metastasis.Radiation research · 2014Review
- Cancer preventive efficacy of marine carotenoid fucoxanthin: cell cycle arrest and apoptosis.Nutrients · 2013Review
- Gadd45a suppresses tumor angiogenesis via inhibition of the mTOR/STAT3 protein pathway.The Journal of biological chemistry · 2013Article
- Gadd45a inhibits cell migration and invasion by altering the global RNA expression.Cancer biology & therapy · 2012Article
- Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT.Neuro-oncology · 2011Article
- Aurora B interaction of centrosomal Nlp regulates cytokinesis.The Journal of biological chemistry · 2010Article
- Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway.Oncogene · 2009Article
- Carfilzomib inhibits the growth of lung adenocarcinoma via upregulation of Gadd45a expression.Journal of Zhejiang University. Science. BArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gadd45a, a growth arrest and DNA-damage gene, plays important roles in the control of cell cycle checkpoints, DNA repair and apoptosis. We show here that Gadd45a is involved in the control of cell contact inhibition and cell-cell adhesion. Gadd45a can serve as an adapter to enhance the interaction between beta-catenin and Caveolin-1, and in turn induces beta-catenin translocation to cell membrane for maintaining cell-cell adhesion/contact inhibition. This is coupled with reduction of beta-catenin in cytoplasm and nucleus following Gadd45a induction, which is reflected by the downregulation of cyclin D1, one of the beta-catenin targeted genes. Additionally, Gadd45a facilitates ultraviolet radiation-induced degradation of cytoplasmic and nuclear beta-catenin in a p53-dependent manner via activation of p38 kinase. These findings define a novel link that connects Gadd45a to cell-cell adhesion and cell contact inhibition, which might contribute to the role of Gadd45a in inhibiting tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.