ArticleThe Journal of experimental medicine2007
Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function.
Article in The Journal of experimental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Immune checkpoint inhibitor-induced myocarditis is dependent on CD8 T cell-derived TNF and TNFR2 signaling.The Journal of experimental medicine · 2026Article
- Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes.Cell reports · 2026Article
- Mechanistic roles and clinical applications of tertiary lymphoid structures in colorectal cancer drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2026Review
- Lymphotoxin beta receptorInfection and immunity · 2025Article
- Effects of combination treatment with durvalumab plus tremelimumab on the tumor microenvironment in non-small-cell lung carcinoma.Cancer immunology, immunotherapy : CII · 2022Article
- Tertiary lymphoid structures are critical for cancer prognosis and therapeutic response.Frontiers in immunology · 2022Review
- Bispecific antibody-mediated redirection of NKG2D-CAR natural killer cells facilitates dual targeting and enhances antitumor activity.Journal for immunotherapy of cancer · 2021Article
- DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node.Frontiers in immunology · 2019Article
- Potential of Cells and Cytokines/Chemokines to Regulate Tertiary Lymphoid Structures in Human Diseases.Immune network · 2016Review
- Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.Nature communications · 2016Article
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- The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity.Cytokine & growth factor reviews · 2014Review
- The Regulation of Immune Responses by DC Derived Type I IFN.Frontiers in immunology · 2013Article
- Genetic Adjuvantation of Recombinant MVA with CD40L Potentiates CD8 T Cell Mediated Immunity.Frontiers in immunology · 2013Article
- Fine-tuning of dendritic cell biology by the TNF superfamily.Nature reviews. Immunology · 2012Review
- Lymphotoxin-sensitive microenvironments in homeostasis and inflammation.Frontiers in immunology · 2012Article
- Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge.Cell host & microbe · 2011Article
- The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.Nature medicine · 2011Article
- Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations.The Journal of experimental medicine · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During an immune response, activated antigen (Ag)-specific T cells condition dendritic cells (DCs) to enhance DC function and survival within the inflamed draining lymph node (LN). It has been difficult to ascertain the role of the tumor necrosis factor (TNF) superfamily member lymphotoxin-alphabeta (LTalphabeta) in this process because signaling through the LTbeta-receptor (LTbetaR) controls multiple aspects of lymphoid tissue organization. To resolve this, we have used an in vivo system where the expression of TNF family ligands is manipulated only on the Ag-specific T cells that interact with and condition Ag-bearing DCs. We report that LTalphabeta is a critical participant required for optimal DC function, independent of its described role in maintaining lymphoid tissue organization. In the absence of LTalphabeta or CD40L on Ag-specific T cells, DC dysfunction could be rescued in vivo via CD40 or LTbetaR stimulation, respectively, suggesting that these two pathways cooperate for optimal DC conditioning.
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