ArticleMolecular and cellular biology2007
HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Pan-cancer exploration of oncogenic and clinical impacts revealed that HOXA9 is a diagnostic indicator of tumorigenesis.Clinical and experimental medicine · 2024Article
- HOXA9 transcription factor is a double-edged sword: from development to cancer progression.Cancer metastasis reviews · 2024Review
- Deciphering the emerging landscape of HOX genes in cardiovascular biology, atherosclerosis and beyond (Review).International journal of molecular medicine · 2024Article
- Role of HOXA9 in solid tumors: mechanistic insights and therapeutic potential.Cancer cell international · 2022Review
- HOXA9 inhibitors promote microcirculation of coronary arteries in rats via downregulating E-selectin/VCAM-1.Experimental and therapeutic medicine · 2021Article
- High level of homeobox A9 and PBX homeobox 3 expression in gastric cancer correlates with poor prognosis.Oncology letters · 2017Article
- The Role of Protein Arginine Methyltransferases in Inflammatory Responses.Mediators of inflammation · 2016Review
- HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Tumor necrosis factor (TNF)-α induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-κB p65 methylation.The Journal of biological chemistry · 2014Article
- Adipose tissue angiogenesis: impact on obesity and type-2 diabetes.Biochimica et biophysica acta · 2014Review
- Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.Science signaling · 2013Article
- HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules.Molecular and cellular biology · 2012Article
- Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils.PloS one · 2011Article
- The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis.Critical reviews in oncogenesis · 2011Review
- Environment and vascular bed origin influence differences in endothelial transcriptional profiles of coronary and iliac arteries.American journal of physiology. Heart and circulatory physiology · 2010Article
- Thrombin induces endothelial arginase through AP-1 activation.American journal of physiology. Cell physiology · 2010Article
- Persistent inflammation and angiogenesis during wound healing in K14-directed Hoxb13 transgenic mice.The Journal of investigative dermatology · 2010Article
- Transcriptional targeting of tumor endothelial cells for gene therapy.Advanced drug delivery reviews · 2009Review
- Hox specificity unique roles for cofactors and collaborators.Current topics in developmental biology · 2009Review
- Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
The homeobox gene HOXA9 has recently been shown to be an important regulator of endothelial cell (EC) differentiation and activation in addition to its role in embryonic development and hematopoiesis. In this report, we have determined that the EC-leukocyte adhesion molecule E-selectin is a key target for HOXA9. The depletion of HOXA9 protein in ECs resulted in a significant and specific decrease in tumor necrosis factor alpha (TNF-alpha)-induced E-selectin gene expression. In addition, HOXA9 specifically activated the E-selectin gene promoter in ECs. Progressive deletional analyses together with site-specific mutagenesis of the E-selectin promoter indicated that the Abd-B-like HOX DNA-binding motif, CAATTTTATTAA, located in the proximal region spanning bp -210 to -221 upstream of the transcription start site was crucial for the promoter induction by HOXA9. Both HOXA9 in EC nuclear extract and recombinant HOXA9 protein bound to this sequence in vitro. Moreover, we showed that HOXA9 binds temporally, in a TNF-alpha-dependent manner, to the region containing this Abd-B-like element in vivo. We have thus identified a novel and functionally critical cis-regulatory element for TNF-alpha-mediated transient expression of the E-selectin gene. Further, we provide evidence that HOXA9 acts as an obligate proinflammatory factor by mediating cytokine induction of E-selectin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.