ArticleMolecular and cellular biology2007
Yra1 is required for S phase entry and affects Dia2 binding to replication origins.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain.PloS one · 2019Article
- Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening.PLoS genetics · 2016Article
- The nuclear protein ALY binds to and modulates the activity of transcription factor E2F2.Molecular & cellular proteomics : MCP · 2013Article
- Hect E3 ubiquitin ligase Tom1 controls Dia2 degradation during the cell cycle.Molecular biology of the cell · 2012Article
- Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.BMC cancer · 2011Article
- Article
- RNA processing and export.Cold Spring Harbor perspectives in biology · 2010Review
- Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export.Genes & development · 2010Article
- The replication stress response and the ubiquitin system: a new link in maintaining genomic integrity.Cell division · 2010Article
- Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2.Molecular and cellular biology · 2010Article
- SCF(Dia2) regulates DNA replication forks during S-phase in budding yeast.The EMBO journal · 2009Article
- Lessons from fungal F-box proteins.Eukaryotic cell · 2009Review
- Article
- Akt phosphorylation and nuclear phosphoinositide association mediate mRNA export and cell proliferation activities by ALY.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae.DNA repair · 2008Article
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The Saccharomyces cerevisiae F-box protein Dia2 is important for DNA replication and genomic stability. Using an affinity approach, we identified Yra1, a transcription-coupled mRNA export protein, as a Dia2 interaction partner. We find that yra1 mutants are sensitive to DIA2 expression levels. Like Dia2, Yra1 associates with chromatin and binds replication origins, suggesting that they may function together in DNA replication. Consistent with this idea, Yra1 and Dia2 coimmunoprecipitate with Hys2, a subunit of DNA polymerase delta. The C terminus of Yra1 is required to interact with Dia2. A yra1 mutant that lacks this domain is temperature sensitive yet has no apparent defect in RNA export. Remarkably, this mutant also fails to enter S phase at the nonpermissive temperature. Significantly, other mutants in transcription-coupled export do not exhibit S phase entry defects or sensitivity to DIA2 expression levels. Together, these results indicate that Yra1 has a role in DNA replication distinct from its role in mRNA export. Furthermore, Dia2 binding to replication origins is significantly reduced when association with Yra1 is compromised, suggesting that one aspect of the role of Yra1 in DNA replication may involve recruiting Dia2 to chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.