ArticleMolecular and cellular biology2007
Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Muscle-Specific Kinase Signaling and Its Therapeutic Potential.Muscle & nerve · 2026Review
- ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling.Molecular oncology · 2025Article
- Case Report: Compound heterozygousFrontiers in genetics · 2025Article
- Identification of the Factor That Leads Human Mesenchymal Stem Cell Lines into Decellularized Bone.Bioengineering (Basel, Switzerland) · 2022Article
- SHC4 promotes tumor proliferation and metastasis by activating STAT3 signaling in hepatocellular carcinoma.Cancer cell international · 2022Article
- The Role of p66Shc in Diabetes: A Comprehensive Review from Bench to Bedside.Journal of diabetes research · 2022Review
- Protective Effects of ShcA Protein Silencing for Photothrombotic Cerebral Infarction.Translational stroke research · 2021Article
- Adaptor Protein ShcD/Molecular cancer research : MCR · 2021Article
- Downregulation of SHCBP1 Inhibits Proliferation, Migration, and Invasion in Human Nasopharyngeal Carcinoma Cells.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Localization of phosphotyrosine adaptor protein ShcD/SHC4 in the adult rat central nervous system.BMC neuroscience · 2019Article
- Role of TGF‑β in the motility of ShcD‑overexpressing 293 cells.Molecular medicine reports · 2019Article
- Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors.Molecular & cellular proteomics : MCP · 2018Article
- The role of the ShcD and RET interaction in neuroblastoma survival and migration.Biochemistry and biophysics reports · 2018Article
- Insights into the Shc Family of Adaptor Proteins.Journal of molecular signaling · 2017Article
- Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors.The Journal of biological chemistry · 2017Article
- MuSK Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase Loop.Scientific reports · 2016Article
- Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor.The Biochemical journal · 2016Article
- Cell density modulates SHC3 expression and survival of human glioblastoma cells through Fak activation.Journal of neuro-oncology · 2014Article
- Biologically active substances-enriched diet regulates gonadotrope cell activation pathway in liver of adult and old rats.Genes & nutrition · 2014Article
- The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor.Molecular biology of the cell · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Shc family proteins serve as phosphotyrosine adaptor molecules in various receptor-mediated signaling pathways. In mammals, three distinct Shc genes have been described that encode proteins characterized by two phosphotyrosine-interaction modules, an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Here, we report the analysis of an uncharacterized fourth Shc family protein, ShcD/Shc4, that is expressed in adult brain and skeletal muscle. Consistent with this expression pattern, we find that ShcD can associate via its PTB domain with the phosphorylated muscle-specific kinase (MuSK) receptor tyrosine kinase and undergo tyrosine phosphorylation downstream of activated MuSK. Interestingly, additional sites of tyrosine phosphorylation, including a novel Grb2 binding site, are present on ShcD that are not found in other Shc family proteins. Activation of MuSK upon agrin binding at the neuromuscular junction (NMJ) induces clustering and tyrosine phosphorylation of acetylcholine receptors (AChRs) required for synaptic transmission. ShcD is coexpressed with MuSK in the postsynaptic region of the NMJ, and in cultured myotubes stimulated with agrin, expression of ShcD appears to be important for early tyrosine phosphorylation of the AChR. Thus, we have characterized a new member of the Shc family of docking proteins, which may mediate a specific aspect of signaling downstream of the MuSK receptor.
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