ArticleTraffic (Copenhagen, Denmark)2007
The role of cargo proteins in GGA recruitment.
Article in Traffic (Copenhagen, Denmark), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation.Molecular biology of the cell · 2021Article
- Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins.Molecular biology of the cell · 2018Article
- GGA2 interacts with EGFR cytoplasmic domain to stabilize the receptor expression and promote cell growth.Scientific reports · 2018Article
- CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.The Journal of biological chemistry · 2017Article
- Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Impact of genetic background on neonatal lethality of Gga2 gene-trap mice.G3 (Bethesda, Md.) · 2014Article
- Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex.The Journal of biological chemistry · 2013Article
- A role for cargo in Arf-dependent adaptor recruitment.The Journal of biological chemistry · 2013Article
- Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development.PloS one · 2012Article
- A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis.BMC cell biology · 2011Article
- A screen for endocytic motifs.Traffic (Copenhagen, Denmark) · 2010Article
- Toward a model for Arf GTPases as regulators of traffic at the Golgi.FEBS letters · 2009Review
- Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.The Journal of cell biology · 2008Article
- EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Intracellular trafficking of LRP9 is dependent on two acidic cluster/dileucine motifs.Histochemistry and cell biology · 2008Article
- Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution.The EMBO journal · 2008Article
- Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.Molecular biology of the cell · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Coat proteins are recruited onto membranes to form vesicles that transport cargo from one compartment to another, but the extent to which the cargo helps to recruit the coat proteins is still unclear. Here we have examined the role of cargo in the recruitment of Golgi-localized, gamma-ear-containing, ADP ribosylation factor (ARF)-binding proteins (GGAs) onto membranes in HeLa cells. Moderate overexpression of CD8 chimeras with cytoplasmic tails containing DXXLL-sorting signals, which bind to GGAs, increased the localization of all three GGAs to perinuclear membranes, as observed by immunofluorescence. GGA2 was also expressed at approximately twofold higher levels in these cells because it was degraded more slowly. However, this difference only partially accounted for the increase in membrane localization because there was a approximately fivefold increase in GGA2 associated with crude membranes and a approximately 12-fold increase in GGA2 associated with clathrin-coated vesicles (CCVs) in cells expressing CD8-DXXLL chimeras. The effect of cargo proteins on GGA recruitment was reconstituted in vitro using permeabilized control and CD8-DXXLL-expressing cells incubated with cytosol containing recombinant GGA2 constructs. Together, these results demonstrate that cargo proteins contribute to the recruitment of GGAs onto membranes and to the formation of GGA-positive CCVs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.