ArticleAlcoholism, clinical and experimental research2007
Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains.
Article in Alcoholism, clinical and experimental research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction.Frontiers in neuroscience · 2022Article
- Genetic Vulnerability to Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Genetically selected alcohol-preferring msP rats to study alcohol use disorder: Anything lost in translation?Neuropharmacology · 2021Review
- Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring.PeerJ · 2020Article
- Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.Journal of neuroinflammation · 2018Article
- Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice.Genes, brain, and behavior · 2017Article
- Analyses of differentially expressed genes after exposure to acute stress, acute ethanol, or a combination of both in mice.Alcohol (Fayetteville, N.Y.) · 2017Article
- Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight.Journal of genetics and genomics = Yi chuan xue bao · 2016Article
- XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Genetics and genomics of alcohol sensitivity.Molecular genetics and genomics : MGG · 2014Review
- Gene expression within the extended amygdala of 5 pairs of rat lines selectively bred for high or low ethanol consumption.Alcohol (Fayetteville, N.Y.) · 2013Article
- Changes in gene expression within the ventral tegmental area following repeated excessive binge-like alcohol drinking by alcohol-preferring (P) rats.Alcohol (Fayetteville, N.Y.) · 2013Article
- Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2.Alcohol (Fayetteville, N.Y.) · 2013Article
- Genetically selected alcohol preferring rats to model human alcoholism.Current topics in behavioral neurosciences · 2013Article
- Gene Expression Under the Influence: Transcriptional Profiling of Ethanol in the Brain.Current psychopharmacology · 2012Article
- Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study.BMC genomics · 2012Article
- The complexity of alcohol drinking: studies in rodent genetic models.Behavior genetics · 2010Review
- Article
- Identification of genes influencing skeletal phenotypes in congenic P/NP rats.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Consilience of rodent and human phenotypes relevant for alcohol dependence.Addiction biology · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA highly significant quantitative trait locus (QTL) on chromosome 4 that influenced alcohol preference was identified by analyzing crosses between the iP and iNP rats. Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains.
methodsRNA from 5 brain regions from each of 6 NP.P and 6 iNP rats was labeled and analyzed separately on an Affymetrix Rat Genome 230 2.0 microarray to look for both cis-regulated and trans-regulated genes. Expression levels were normalized using robust multi-chip average (RMA). Differential gene expression was validated using quantitative real-time polymerase chain reaction. Five individual brain regions (nucleus accumbens, frontal cortex, amygdala, hippocampus, and striatum) were analyzed to detect differential expression of genes within the introgressed QTL interval, as well as genes outside that region. To increase the power to detect differentially expressed genes, combined analyses (averaging data from the 5 discrete brain regions of each animal) were also carried out.
resultsAnalyses within individual brain regions that focused on genes within the QTL interval detected differential expression in all 5 brain regions; a total of 35 genes were detected in at least 1 region, ranging from 6 genes in the nucleus accumbens to 22 in the frontal cortex. Analysis of the whole genome detected very few differentially expressed genes outside the QTL. Combined analysis across brain regions was more powerful. Analysis focused on the genes within the QTL interval confirmed 19 of the genes detected in individual regions and detected 15 additional genes. Whole genome analysis detected 1 differentially expressed gene outside the interval.
conclusionsCis-regulated candidate genes for alcohol consumption were identified using microarray profiling of gene expression differences in congenic animals carrying a QTL for alcohol preference.
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