ArticleJournal of assisted reproduction and genetics2007
Silver-Russell syndrome in a girl born after in vitro fertilization: partial hypermethylation at the differentially methylated region of PEG1/MEST.
Article in Journal of assisted reproduction and genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 199 citations in OpenAlex.
- Comprehensive meta-analysis reveals association between multiple imprinting disorders and conception by assisted reproductive technology.Journal of assisted reproduction and genetics · 2018Pooled it
- Review
- Review
- Crosstalk Between Oxidative Stress and Epigenetics: Unveiling New Biomarkers in Human Infertility.Cells · 2024Review
- Effects of Cryopreservation on Sperm with Cryodiluent in Viviparous Black Rockfish (International journal of molecular sciences · 2022Article
- Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease.Scientific reports · 2021Article
- Association of Assisted Reproductive Technology Treatments with Imprinting Disorders.Global medical genetics · 2021Review
- Biophysical optimization of preimplantation embryo culture: what mechanics can offer ART.Molecular human reproduction · 2021Review
- Perturbations in imprinted methylation from assisted reproductive technologies but not advanced maternal age in mouse preimplantation embryos.Clinical epigenetics · 2019Article
- Reactive oxygen species-induced alterations in H19-Igf2 methylation patterns, seminal plasma metabolites, and semen quality.Journal of assisted reproduction and genetics · 2019Article
- Characterization of multi-locus imprinting disturbances and underlying genetic defects in patients with chromosome 11p15.5 related imprinting disorders.Epigenetics · 2018Article
- Maintenance ofEnvironmental epigenetics · 2017Review
- Epigenetic modifications at DMRs of placental genes are subjected to variations in normal gestation, pathological conditions and folate supplementation.Scientific reports · 2017Article
- Imprinting alterations in sperm may not significantly influence ART outcomes and imprinting patterns in the cord blood of offspring.PloS one · 2017Article
- High Frequency of Imprinted Methylation Errors in Human Preimplantation Embryos.Scientific reports · 2015Article
- Epigenetic Alterations in Density Selected Human Spermatozoa for Assisted Reproduction.PloS one · 2015Article
- Review
- Imprinting methylation errors in ART.Reproductive medicine and biology · 2014Article
- Silver-Russell syndrome due to paternal H19/IGF2 hypomethylation in a twin girl born after in vitro fertilization.American journal of medical genetics. Part A · 2013Article
- Embryo manipulation via assisted reproductive technology and epigenetic asymmetry in mammalian early development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe prevalence of low birth weight (LBW) is increased in subjects born after assisted reproduction technology (ART), and defective imprinting has frequently been identified in patients with Beckwith-Wiedermann and Angelman syndromes conceived by ART. Thus, we examined methylation pattern in a girl born after ART who had Silver-Russell syndrome (SRS) which can be caused by maternal uniparental disomy for chromosome 7 and by hypomethylation of the differentially methylated region (DMR) of H19.
methodsWe examined methylation status of 31 cytosines at the CpG dinucleotides in the DMR of PEG1/MEST on 7q32.2 and 23 cytosines at the CpG dinucleotides in the DMR of H19 on 11p15, using leukocyte genomic DNA.
resultsEight of the 31 cytosines in the patient and four of the 31 cytosines in the father were hypermethylated in the PEG1/MEST-DMR. In the H19-DMR, no abnormal methylation pattern was identified in the patient.
conclusionThe results suggest that hypermethylation of paternally expressed genes including PEG1/MEST, which usually have growth-promoting effects, may be relevant to LBW in subjects conceived by ART.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.