Evidence map›Paper›PMID 17450386›Full record

ArticlePediatric nephrology (Berlin, Germany)2007

Expression profiles of congenital renal dysplasia reveal new insights into renal development and disease.

Sanjay Jain, Adrian A Suarez, John McGuire, Helen Liapis

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Aberrations inInternational journal of molecular sciences · 2022
    Article
  3. Definition, diagnosis and clinical management of non-obstructive kidney dysplasia: a consensus statement by the ERKNet Working Group on Kidney Malformations.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022
    Article
  4. Article
  5. Article
  6. The Good and Bad of β-Catenin in Kidney Development and Renal Dysplasia.Frontiers in cell and developmental biology · 2015
    Review
  7. Glypican 3 overexpression in primary and metastatic Wilms tumors.Virchows Archiv : an international journal of pathology · 2015
    Article
  8. Article
  9. The renal biopsy in the genomic era.Pediatric nephrology (Berlin, Germany) · 2013
    Review
  10. Double homozygous missense mutations in DACH1 and BMP4 in a patient with bilateral cystic renal dysplasia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2013
    Article
  11. Matrilysin (MMP-7) inhibition of BMP-7 induced renal tubular branching morphogenesis suggests a role in the pathogenesis of human renal dysplasia.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012
    Article
  12. Expression profiles of podocytes exposed to high glucose reveal new insights into early diabetic glomerulopathy.Laboratory investigation; a journal of technical methods and pathology · 2011
    Article
  13. β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1.Journal of the American Society of Nephrology : JASN · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sanjay JainDepartment of Medicine (Renal Division), Washington University School of Medicine, Saint Louis, MO, 63110, USA.
Adrian A Suarez
John McGuire
Helen Liapis
Washington University in St. Louis · US

Funding

Functional Dissection of Ret Signaling PathwaysK08HD047396 · NICHD · WASHINGTON UNIVERSITY · PI JAIN, SANJAY · 2004 to 2008
$742k
NICHD NIH HHS HD047396NICHD NIH HHS K08 HD047396NICHD NIH HHS L40 HD045452
6 · The paper itself

Abstract

Congenital renal dysplasia (RD) is a major cause of renal failure in the pediatric population. Although molecular and genetic aspects of RD have been studied in animal models, limited studies have been done in human RD primarily due to lack of available material. To identify novel genes that are associated with RD and normal kidney development, we performed microarray analysis on total RNA extracted from age-matched fetal kidneys of normal and RD patients. In midgestational RD kidneys, we found 180 upregulated and 104 downregulated transcripts compared with normal kidneys. Among the increased transcripts in the dysplastic kidneys were matrix-degrading enzymes (MMP7, MMP19, TIMP1), inflammation- and immunity-related genes, and growth factors. Expression of genes known to be essential for normal kidney development, such as WT1, BMP7, renin, angiotensin receptor 2 (AGTR2), SAL-like 1 (SALL1) and glypican 3 (GPC3), were decreased in dysplastic kidneys. Expression of selected gene products (BMP7, renin, and MMP7) was further confirmed in parallel sections and in several normal and human dysplastic kidneys, supporting the role of these genes as putative RD biomarkers. These results are among the first to reveal disrupted expression profiles during gestation in human RD patients.

Indexed as

Gene ExpressionTranscription, GeneticBone Morphogenetic Protein 7Bone Morphogenetic ProteinsCase-Control StudiesFetusGestational AgeHumansImmunohistochemistryKidneyKidney Diseases, CysticMatrix Metalloproteinase 7Oligonucleotide Array Sequence AnalysisReninBMP7 protein, humanBone Morphogenetic Protein 7Bone Morphogenetic ProteinsMatrix Metalloproteinase 7MMP7 protein, humanRenin

Identifiers

PMID17450386
OpenAlexW2003198752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.