ArticleVirchows Archiv : an international journal of pathology2007
Serrated polyps of the colorectum: is sessile serrated adenoma distinguishable from hyperplastic polyp in a daily practice?
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Endoscopic diagnosis of sessile serrated polyp: A systematic review.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2019Pooled it
- Cap assisted colonoscopy for the detection of serrated polyps: a post-hoc analysis.BMC gastroenterology · 2015Trial
- Specific Targeting and Labeling of Colonic Polyps inCurrent issues in molecular biology · 2023Article
- Sporadic hyperplastic polyp associated with above-average risk of developing metachronous colorectal cancer.American journal of cancer research · 2023Article
- Hyperplastic polyp or sessile serrated lesion? The contribution of serial sections to reclassification.Diagnostic pathology · 2020Article
- Increased Risk of Colorectal Cancer Tied to Advanced Colorectal Polyps: An Untapped Opportunity to Screen First-Degree Relatives and Decrease Cancer Burden.The American journal of gastroenterology · 2020Review
- Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Colorectal Serrated Neoplasia: An Institutional 12-Year Review Highlights the Impact of a Screening Programme.Gastroenterology research and practice · 2019Article
- Smoking and Other Risk Factors in Individuals With Synchronous Conventional High-Risk Adenomas and Clinically Significant Serrated Polyps.The American journal of gastroenterology · 2018Article
- Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions.Digestive diseases and sciences · 2018Review
- Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: clinical implication for improved colon surveillance.Oncotarget · 2017Article
- Investigating The Frequency of Serrated Polyps/Adenomas and Their Subtypes in Colonic Polyp Samples.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2016Article
- Factors associated with reclassification of hyperplastic polyps after pathological reassessment from screening and surveillance colonoscopies.International journal of colorectal disease · 2016Article
- Histology subtypes and polyp size are associated with synchronous colorectal carcinoma of colorectal serrated polyps: a study of 499 serrated polyps.American journal of cancer research · 2015Article
- DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability.BMC cancer · 2014Article
- Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics.Virchows Archiv : an international journal of pathology · 2014Article
- Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management.Journal of gastroenterology · 2013Review
- Serrated polyps of the colon: how reproducible is their classification?Virchows Archiv : an international journal of pathology · 2012Article
- Serrated lesions of the colorectum: review and recommendations from an expert panel.The American journal of gastroenterology · 2012Article
- Externalization of saw-tooth architecture in small serrated polyps implies the presence of methylation of IGFBP7.Digestive diseases and sciences · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distinction between serrated polyps of the colon is complex, particularly between hyperplastic polyps (HP) and sessile serrated adenomas (SSA). Recent data show that SSA might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. We characterized the demographic and pathologic characteristics of 102 serrated lesions among 321 polyps of the colorectum and determined if SSA can be microscopically distinguished from HP in biopsy material of a daily practice. There were 81 HP (79%) and 7 SSA (7%) of which one displayed low-grade dysplasia. Only six serrated polyps (6%) could not be correctly classified. The main architectural criteria for distinguishing SSA from HP is the serrated feature along the crypt axis and the rarity of undifferentiated cells in the lower third of the crypts. SSA was significantly more often located in the right colon and larger (median, 11 vs 4 mm) than HP. SSA are rare serrated polyps that can be distinguished from HP based on their morphology, location in the right colon, and larger size. One SSA of our series showed low-grade dysplasia supporting the concept that this lesion might be a precursor of serrated adenocarcinoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.