ArticleEnvironmental health perspectives2007
Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.Allergy · 2009Pooled it
- Genetics of Asthma and Allergic Diseases.Handbook of experimental pharmacology · 2022Article
- Genetics and Gene-Environment Interactions in Childhood and Adult Onset Asthma.Frontiers in pediatrics · 2019Review
- Gene-Environment Interactions-What Can These Tell Us about the Relationship between Asthma and Allergy?Frontiers in pediatrics · 2017Review
- Gene-environment interaction from international cohorts: impact on development and evolution of occupational and environmental lung and airway disease.Seminars in respiratory and critical care medicine · 2015Review
- Asthma in Hispanics. An 8-year update.American journal of respiratory and critical care medicine · 2014Review
- Outdoor air pollution and asthma.Lancet (London, England) · 2014Review
- GSTP1 and TNF Gene variants and associations between air pollution and incident childhood asthma: the traffic, asthma and genetics (TAG) study.Environmental health perspectives · 2014Article
- The tumor necrosis factor α (-308 A/G) polymorphism is associated with cystic fibrosis in Mexican patients.PloS one · 2014Article
- Modifiable exposures to air pollutants related to asthma phenotypes in the first year of life in children of the EDEN mother-child cohort study.BMC public health · 2013Article
- Genetics of asthma susceptibility and severity.Clinics in chest medicine · 2012Review
- Perinatal gene-gene and gene-environment interactions on IgE production and asthma development.Clinical & developmental immunology · 2012Review
- Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.Nature genetics · 2011Article
- Allergic asthma: influence of genetic and environmental factors.The Journal of biological chemistry · 2011Review
- Gene-environment interactions in human disease: nuisance or opportunity?Trends in genetics : TIG · 2011Review
- A methodology to establish a database to study gene environment interactions for childhood asthma.BMC medical research methodology · 2010Article
- Unifying candidate gene and GWAS Approaches in Asthma.PloS one · 2010Article
- Case-only gene-environment interaction studies: when does association imply mechanistic interaction?Genetic epidemiology · 2010Article
- Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease.Environmental health perspectives · 2008Article
- Gene-air pollution interactions in asthma.Proceedings of the American Thoracic Society · 2007Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPolymorphisms in the proinflammatory cytokine genes tumor necrosis factor-alpha (TNF) and lymphotoxin-alpha (LTA, also called TNF-beta) have been associated with asthma and atopy in some studies. Parental smoking is a consistent risk factor for childhood asthma. Secondhand smoke and ozone both stimulate TNF production.
objectivesOur goal was to investigate whether genetic variation in TNF and LTA is associated with asthma and atopy and whether the association is modified by parental smoking in a Mexican population with high ozone exposure.
methodsWe genotyped six tagging single nucleotide polymorphisms (SNPs) in TNF and LTA, including functional variants, in 596 nuclear families consisting of asthmatics 4-17 years of age and their parents in Mexico City. Atopy was determined by skin prick tests.
resultsThe A allele of the TNF-308 SNP was associated with increased risk of asthma [relative risk (RR) = 1.54; 95% confidence interval (CI), 1.04-2.28], especially among children of non-smoking parents (RR = 2.06; 95% CI, 1.19-3.55; p for interaction = 0.09). Similarly, the A allele of the TNF-238 SNP was associated with increased asthma risk among children of nonsmoking parents (RR = 2.21; 95% CI, 1.14-4.30; p for interaction = 0.01). LTA SNPs were not associated with asthma. Haplotype analyses reflected the single SNP findings in magnitude and direction. TNF and LTA SNPs were not associated with the degree of atopy.
conclusionsOur results suggest that genetic variation in TNF may contribute to childhood asthma and that associations may be modified by parental smoking.
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