ArticleEnvironmental health perspectives2007
Up-regulation of tissue factor in human pulmonary artery endothelial cells after ultrafine particle exposure.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Ambient Ultrafine Particles and Hypertensive Disorders of Pregnancy: A Mediation Analysis of Homocysteine in a Birth Cohort.Environment & health (Washington, D.C.) · 2026Article
- The Associations of Air Pollution Mixture Exposure with Plasma Proteins in an Elderly U.S. Panel.Environmental science & technology · 2025Article
- Inhibitory Effects of 3-Deoxysappanchalcone on Particulate-Matter-Induced Pulmonary Injury.Current issues in molecular biology · 2025Article
- Overview of the Mechanisms of Oxidative Stress: Impact in Inflammation of the Airway Diseases.Antioxidants (Basel, Switzerland) · 2022Review
- Systems level insights into the impact of airborne exposure on SARS-CoV-2 pathogenesis and COVID-19 outcome - A multi-omics big data study.Gene reports · 2021Article
- Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials.Scientific data · 2021Article
- Oleic acid and derivatives affect human endothelial cell mitochondrial function and vasoactive mediator production.Lipids in health and disease · 2020Article
- Pure ultra-fine carbon particles do not exert pro-coagulation and inflammatory effects on microvascular endothelial cells.Environmental science and pollution research international · 2019Article
- Capturing context-specific regulation in molecular interaction networks.BMC bioinformatics · 2018Article
- Identification of RNA biomarkers for chemical safety screening in mouse embryonic stem cells using RNA deep sequencing analysis.PloS one · 2017Article
- Article
- Ultrafine carbon particle mediated cardiovascular impairment of aged spontaneously hypertensive rats.Particle and fibre toxicology · 2014Article
- Altered gene transcription in human cells treated with Ludox® silica nanoparticles.International journal of environmental research and public health · 2014Article
- Air pollution upregulates endothelial cell procoagulant activity via ultrafine particle-induced oxidant signaling and tissue factor expression.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- NanoMiner - integrative human transcriptomics data resource for nanoparticle research.PloS one · 2013Article
- Hydrogen sulfide attenuates particulate matter-induced human lung endothelial barrier disruption via combined reactive oxygen species scavenging and Akt activation.American journal of respiratory cell and molecular biology · 2012Article
- Alterations of specific biomarkers of metabolic pathways in vascular tree from patients with Type 2 diabetes.Cardiovascular diabetology · 2012Article
- Manufactured and airborne nanoparticle cardiopulmonary interactions: a review of mechanisms and the possible contribution of mast cells.Inhalation toxicology · 2012Review
- Combination effects of cigarette smoke extract and ambient ultrafine particles on endothelial cells.Toxicology in vitro : an international journal published in association with BIBRA · 2012Article
- The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children.BMC public health · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEpidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, but the mechanisms remain unknown.
objectivesWe tested the hypothesis that the ultrafine fraction of ambient pollutant particles would cause endothelial cell dysfunction.
methodsWe profiled gene expression of human pulmonary artery endothelial cells (HPAEC) exposed to ultrafine particles (UFPs; 100 microg/mL) from Chapel Hill, North Carolina, or vehicle for 4 hr with Affymetrix HG U133 Plus 2.0 chips (n = 4 each).
resultsWe found 320 up-regulated genes and 106 down-regulated genes (p < 0.01, 5% false discovery rate). We noted up-regulation of genes related to coagulation [tissue factor (F3) and coagulation factor II receptor-like 2 (F2RL2)] and differential regulation of genes related to F3 signaling (FOS, JUN, and NFKBIA). Results of quantitative polymerase chain reaction show a significant up-regulation of F3 after 10 and 100 microg/mLUFP exposures. Additionally, the water-soluble fractions of UFPs were sufficient to induce the expression of F3, F2RL2, and heme oxygenase 1 (HMOX1). Treatment of HPAEC with UFPs for 16 hr increased the release of interleukin (IL)-6 and IL-8. Pretreatment of HPAEC with a blocking antibody against F3 attenuated IL-6 and IL-8 release by 30 and 70%, respectively.
conclusionsUsing gene profiling, we discovered that UFPs may induce vascular endothelial cells to express genes related to clotting. These results indicate that PM may cause adverse cardiovascular health effects by activating coagulation-inflammation circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.