ArticleApplied and environmental microbiology2007
Detection and transformation of genome segments that differ within a coastal population of Vibrio cholerae strains.
Article in Applied and environmental microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Impact of Natural Transformation on the Acquisition of Novel Genes in Bacteria.Molecular biology and evolution · 2025Article
- Exploring Mobile Genetic Elements in Vibrio cholerae.Genome biology and evolution · 2025Article
- CryoEM structure of the type IVa pilus secretin required for natural competence in Vibrio cholerae.Nature communications · 2020Article
- Interbacterial competition and anti-predatory behaviour of environmental Vibrio cholerae strains.Environmental microbiology · 2020Article
- Comparison of chitin-induced natural transformation in pandemic Vibrio cholerae O1 El Tor strains.Environmental microbiology · 2020Article
- Neighbor predation linked to natural competence fosters the transfer of large genomic regions ineLife · 2019Article
- Microbial Surface Colonization and Biofilm Development in Marine Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
- TfoX-based genetic mapping identifies Vibrio fischeri strain-level differences and reveals a common lineage of laboratory strains.Journal of bacteriology · 2015Article
- Article
- Competence and natural transformation in vibrios.Molecular microbiology · 2013Article
- A quorum sensing-mediated switch contributes to natural transformation of Vibrio cholerae.Mobile genetic elements · 2012Article
- Identification of a chitin-induced small RNA that regulates translation of the tfoX gene, encoding a positive regulator of natural competence in Vibrio cholerae.Journal of bacteriology · 2011Article
- Recombination shapes the structure of an environmental Vibrio cholerae population.Applied and environmental microbiology · 2011Article
- Evidence for the horizontal transfer of an unusual capsular polysaccharide biosynthesis locus in marine bacteria.Infection and immunity · 2010Article
- Comparative genomics of the family Vibrionaceae reveals the wide distribution of genes encoding virulence-associated proteins.BMC genomics · 2010Article
- Natural transformation of Vibrio cholerae as a tool--optimizing the procedure.BMC microbiology · 2010Article
- Comparative evolutionary analysis of the major structural subunit of Vibrio vulnificus type IV pili.Molecular biology and evolution · 2009Article
- Molecular diversification in the quorum-sensing system of Vibrio cholerae: Role of natural selection in the emergence of pandemic strains.Applied and environmental microbiology · 2009Article
- Biogeographic patterns in genomic diversity among a large collection of Vibrio cholerae isolates.Applied and environmental microbiology · 2009Article
- Diversity and seasonality of bioluminescent Vibrio cholerae populations in Chesapeake Bay.Applied and environmental microbiology · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio cholerae is an autochthonous member of diverse aquatic ecosystems around the globe. Collectively, the genomes of environmental V. cholerae strains comprise a large repository of encoded functions which can be acquired by individual V. cholerae lineages through uptake and recombination. To characterize the genomic diversity of environmental V. cholerae, we used comparative genome hybridization to study 41 environmental strains isolated from diverse habitats along the central California coast, a region free of endemic cholera. These data were used to classify genes of the epidemic V. cholerae O1 sequenced strain N16961 as conserved, variably present, or absent from the isolates. For the most part, absent genes were restricted to large mobile elements and have known functions in pathogenesis. Conversely, genes present in some, but not all, California isolates were in smaller contiguous clusters and were less likely to be near genes with functions in DNA mobility. Two such clusters of variable genes encoding different selectable metabolic phenotypes (mannose and diglucosamine utilization) were transformed into the genomes of environmental isolates by chitin-dependent competence, indicating that this mechanism of general genetic exchange is conserved among V. cholerae. The transformed DNA had an average size of 22.7 kbp, demonstrating that natural competence can mediate the movement of large chromosome fragments. Thus, whether variable genes arise through the acquisition of new sequences by horizontal gene transfer or by the loss of preexisting DNA though deletion, natural transformation provides a mechanism by which V. cholerae clones can gain access to the V. cholerae pan-genome.
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