ArticleBiophysical journal2007
A hybrid model for erythrocyte membrane: a single unit of protein network coupled with lipid bilayer.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Bending Energy Schemes for Discrete-Spring-Network Structural Modelling of Red Blood Cells.International journal for numerical methods in biomedical engineering · 2025Article
- A particle-based computational model to analyse remodelling of the red blood cell cytoskeleton during malaria infections.PLoS computational biology · 2022Article
- Do Skeletal Dynamics Mediate Sugar Uptake and Transport in Human Erythrocytes?Biophysical journal · 2018Article
- Erythrocyte Aging, Protection via Vesiculation: An Analysis Methodology via Oscillatory Flow.Frontiers in physiology · 2018Article
- Prospects for Human Erythrocyte Skeleton-Bilayer Dissociation during Splenic Flow.Biophysical journal · 2017Article
- Multiscale modeling methods in biomechanics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation.PloS one · 2014Article
- Continuum- and particle-based modeling of shapes and dynamics of red blood cells in health and disease.Soft matter · 2013Article
- Intertwined αβ spectrin meeting helical actin protofilament in the erythrocyte membrane skeleton: wrap-around vs. point-attachment.Annals of biomedical engineering · 2011Article
- Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domain.The Journal of biological chemistry · 2010Article
- Nanomechanics of multiple units in the erythrocyte membrane skeletal network.Annals of biomedical engineering · 2010Article
- Multiscale simulation of erythrocyte membranes.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- Spectrin folding versus unfolding reactions and RBC membrane stiffness.Biophysical journal · 2008Article
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Authors and funding
5 authors.
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Abstract
To investigate the nanomechanics of the erythrocyte membrane we developed a hybrid model that couples the actin-spectrin network to the lipid bilayer. This model features a Fourier space Brownian dynamics model of the bilayer, a Brownian dynamics model of the actin protofilament, and a modified wormlike-chain model of the spectrin (including a cable-dynamics model to predict the oscillation in tension). This model enables us to predict the nanomechanics of single or multiple units of the protein network, the lipid bilayer, and the effect of their interactions. The present work is focused on the attitude of the actin protofilament at the equilibrium states coupled with the elevations of the lipid bilayer through their primary linkage at the suspension complex in deformations. Two different actin-spectrin junctions are considered at the junctional complex. With a point-attachment junction, large pitch angles and bifurcation of yaw angles are predicted. Thermal fluctuations at bifurcation may lead to mode-switching, which may affect the network and the physiological performance of the membrane. In contrast, with a wrap-around junction, pitch angles remain small, and the occurrence of bifurcation is greatly reduced. These simulations suggest the importance of three-dimensional molecular junctions and the lipid bilayer/protein network coupling on cell membrane mechanics.
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