ArticleOccupational and environmental medicine2007
Association of blood lead and homocysteine levels among lead exposed subjects in Vietnam and Singapore.
Article in Occupational and environmental medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity.Metabolites · 2026Review
- Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality.Cardiovascular toxicology · 2024Article
- Lead (Pb) exposure and heart failure risk.Environmental science and pollution research international · 2021Review
- Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults.BMJ nutrition, prevention & health · 2020Article
- Nonlinear association between blood lead and hyperhomocysteinemia among adults in the United States.Scientific reports · 2020Article
- Characterize health and economic vulnerabilities of workers to control the emergence of COVID-19 in an industrial zone in Vietnam.Safety science · 2020Article
- Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?Antioxidants (Basel, Switzerland) · 2019Review
- Association of Bone Turnover Levels with MTHFR Gene Polymorphisms among Pregnant Women in Wuhan, China.Current medical science · 2018Article
- Blood lead, cadmium and mercury in relation to homocysteine and C-reactive protein in women of reproductive age: a panel study.Environmental health : a global access science source · 2017Article
- Association of blood lead levels with methylenetetrahydrofolate reductase polymorphisms among Chinese pregnant women in Wuhan city.PloS one · 2015Article
- Lead exposure, B vitamins, and plasma homocysteine in men 55 years of age and older: the VA normative aging study.Environmental health perspectives · 2014Article
- Association of homocysteine levels with blood lead levels and micronutrients in the US general population.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2012Article
- The protean toxicities of lead: new chapters in a familiar story.International journal of environmental research and public health · 2011Review
- Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan.PloS one · 2010Article
- Methylenetetrahydrofolate reductase ( MTHFR) C677T, A1298C and G1793A genotypes, and the relationship between maternal folate intake, tibia lead and infant size at birth.The British journal of nutrition · 2009Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesLead and homocysteine are both linked to cardiovascular disease. With this in mind, the authors evaluated the relation between blood lead and homocysteine in people aged 19-66 years in two Asian populations.
methodsThis cross-sectional study comprised 183 workers from a lead stabiliser factory in Singapore and 323 workers from a battery factory in Vietnam. Workers were occupationally exposed to lead. Blood lead was analysed using atomic absorption spectrophotometry while plasma homocysteine was measured using high performance liquid chromatography.
resultsChinese subjects had the lowest blood lead levels while the Indians had the highest. Controlling for age, sex and race, an increase of 1 microg/dl in blood lead was associated with an increase of 0.04 micromol/l of homocysteine on the log scale. Gender and ethnicity seemed to be strongly associated with the relation between lead and homocysteine. The positive relation between lead and homocysteine among the Vietnamese subjects was significant (Pearson's r = 0.254, p<0.01). When blood lead levels were divided by quartiles, the correlation coefficient between blood lead levels in the 4th quartile and homocysteine among the Vietnamese was higher (r = 0.405, p<0.01). Overall, an increase of 1 microg/dl in blood lead in all the Vietnamese subjects was associated with an increase of 0.05 micromol/l increase in homocysteine on the log scale. However, in the 4th quartile, the same increase was associated with an increase of 0.41 micromol/l of homocysteine on the log scale.
conclusionsBlood lead was found to be associated with homocysteine levels in this Asian sample. Although we cannot determine causality from cross-sectional data, it is sensible to consider the probability that this relation could explain one of the mechanisms of the impact of lead on the cardiovascular system. More studies would be needed to confirm this inference.
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