ReviewArchives of disease in childhood2007
Recent advances in the diagnosis of childhood tuberculosis.
Review in Archives of disease in childhood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Pooled it
- Pooled it
- Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis.BMC infectious diseases · 2016Pooled it
- Intermittent versus daily therapy for treating tuberculosis in children.The Cochrane database of systematic reviews · 2014Pooled it
- Trial
- Is Short Therapy an Appropriate Regimen for Children and Young Adolescents with Drug-Susceptible Tuberculosis?Pharmaceuticals (Basel, Switzerland) · 2026Review
- Prevalence and predictors of tuberculosis among children in Zambezi District, North-Western Province, Zambia.BMC infectious diseases · 2026Article
- Article
- Comparison of chest radiograph findings in ambulatory and hospitalized children with pulmonary tuberculosis.Pediatric radiology · 2023Article
- The Interferon-Gamma Release Assay versus the Tuberculin Skin Test in the Diagnosis ofVaccines · 2023Article
- Review of Pediatric Tuberculosis in the Aftermath of COVID-19.Clinics and practice · 2022Review
- End-point definition and trial design to advance tuberculosis vaccine development.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Diagnostic performance of culture filtered protein 10-specific perforin in pediatric patients with active tuberculosis.Journal of clinical laboratory analysis · 2020Article
- A three-marker protein biosignature distinguishes tuberculosis from other respiratory diseases in Gambian children.EBioMedicine · 2020Article
- Rapid detection of Mycobacterium tuberculosis in children using blood and urine specimens.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Pre-treatment loss to follow-up among children with multidrug-resistant tuberculosis in South Africa, 2008-2010.PloS one · 2020Article
- Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence.Journal of clinical microbiology · 2019Article
- Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005-2017.BMC infectious diseases · 2019Article
- Comparison of IFN-γ Levels in Children with Tuberculosis Disease (TB) and Latent Tuberculosis Infection (LTBI).Open access Macedonian journal of medical sciences · 2018Article
- Accelerating access to quality TB care for pediatric TB cases through better diagnostic strategy in four major cities of India.PloS one · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children account for a major proportion of the global tuberculosis disease burden, especially in endemic areas. However, the accurate diagnosis of childhood tuberculosis remains a major challenge. This review provides an overview of the most important recent advances in the diagnosis of intrathoracic childhood tuberculosis: (1) symptom-based approaches, including symptom-based screening of exposed children and symptom-based diagnosis of active disease; (2) novel immune-based approaches, including T cell assays and novel antigen-based tests; and (3) bacteriological and molecular methods that are more rapid and/or less expensive than conventional culture techniques for tuberculosis diagnosis and/or drug-resistance testing. Recent advances have improved our ability to diagnose latent infection and active tuberculosis in children, but establishing a diagnosis of either latent infection or active disease in HIV-infected children remains a major challenge, particularly in high-burden settings. Although improved access to diagnosis and treatment is essential, ultimately the burden of childhood tuberculosis is determined by the level of epidemic control achieved in a particular community. Several recent initiatives, in particular the United Nations Millennium Developmental Goals, deal with the problem of poverty and disease in a holistic fashion, but global political commitment is required to support these key initiatives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.