ArticleQJM : monthly journal of the Association of Physicians2007
Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study.
Article in QJM : monthly journal of the Association of Physicians, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Protein, Calcium, Vitamin D Intake and 25(OH)D Status in Normal Weight, Overweight, and Obese Older Adults: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- The association between metabolic syndrome and bone mineral density: a meta-analysis.Endocrine · 2012Pooled it
- Efficacy and Safety of Risedronate in Osteoporosis Subjects with Comorbid Diabetes, Hypertension, and/or Dyslipidemia: A Post Hoc Analysis of Phase III Trials Conducted in Japan.Calcified tissue international · 2016Trial
- The association of lipids and novel non-statin lipid-lowering drug target with osteoporosis: evidence from genetic correlations and Mendelian randomization.BMC musculoskeletal disorders · 2025Article
- Remnant cholesterol is associated with hip BMD and low bone mass in young and middle-aged men: a cross-sectional study.Journal of endocrinological investigation · 2024Article
- Article
- The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- Effects of vitamin D deficiency on blood lipids and bone metabolism: a large cross-sectional study.Journal of orthopaedic surgery and research · 2023Article
- High-density lipoprotein cholesterol levels is negatively associated with intertrochanter bone mineral density in adults aged 50 years and older.Frontiers in endocrinology · 2023Article
- Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population.Journal of personalized medicine · 2022Article
- Association between serum lipid profile, body mass index and osteoporosis in postmenopausal Sudanese women.African health sciences · 2022Article
- Toxoplasma gondii infection as a risk factor for osteoporosis: a case-control study.Parasites & vectors · 2022Article
- Bone Health in Patients with Dyslipidemias: An Underestimated Aspect.International journal of molecular sciences · 2022Review
- Lipid metabolism within the bone micro-environment is closely associated with bone metabolism in physiological and pathophysiological stages.Lipids in health and disease · 2022Review
- Association between Metabolic Syndrome and Osteoporosis: A Systematic Review and Meta-Analysis.International journal of endocrinology · 2021Review
- Anti-inflammatory effects of miRNA-146a induced in adipose and periodontal tissues.Biochemistry and biophysics reports · 2020Article
- Association Between Bone Mineral Density and Lipid Profile in Chinese Women.Clinical interventions in aging · 2020Article
- High Body Mass Index and Triglycerides Help Protect against Osteoporosis in Patients with Type 2 Diabetes Mellitus.Journal of diabetes research · 2020Article
- Lipid profiles as potential mediators linking body mass index to osteoporosis among Chinese adults: the Henan Rural Cohort Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Identification of hypertriglyceridemia based on bone density, body fat mass, and anthropometry in a Korean population.BMC cardiovascular disorders · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundBody mass index (BMI) and bone mineral density (BMD) are positively correlated in several studies, but few data relate bone density, lipid profile and anthropometric measures.
aimTo investigate these relationships in a large, well-characterized cohort of men and women (The Hertfordshire Cohort Study).
methodsMen (n = 465) and women (n = 448) from Hertfordshire, UK were recruited. Information was available on demographic and lifestyle factors, anthropometric measurements, body fat percentage, fasting triglycerides, cholesterol (total, HDL, LDL), apolipoprotein (a) and apolipoprotein (b); bone mineral density (BMD) was recorded at the lumbar spine and total femur.
resultsBMD at the lumbar spine (males r = 0.15, p = 0.001; females r = 0.14, p = 0.003) and total femoral region (males r = 0.18, p = 0.0001; females r = 0.16, p = 0.0008) was related to serum triglyceride level, even after adjustment for waist-hip ratio, age, social class and lifestyle factors, but not if body fat percentage was substituted for waist-hip ratio in the regression model. Fasting HDL cholesterol level was related to lumbar spine BMD in women (r = -0.15, p = 0.001) and total femoral BMD in both sexes (males r = -0.15, p = 0.002; females r = -0.23, p < 0.0001); these relationships were also attenuated by adjustment for body fat percentage but not waist-hip ratio. No relationships were seen between total or LDL cholesterol with BMD. DISCUSSION: In this cohort, relationships between lipid profile and BMD were robust to adjustment for one measure of central obesity (waist-hip ratio), but not total body fat. This broadly supports the idea that adiposity may confound the relationship between lipids and bone mass.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.