ArticleNeurotoxicity research2007
Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1.
Article in Neurotoxicity research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- Trial
- Canonical Correlation Analysis of Imaging Genetics Data Based on Statistical Independence and Structural Sparsity.IEEE journal of biomedical and health informatics · 2020Article
- DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- High-resolution chromosome ideogram representation of recognized genes for bipolar disorder.Gene · 2016Article
- Locus Ceruleus Norepinephrine Release: A Central Regulator of CNS Spatio-Temporal Activation?Frontiers in synaptic neuroscience · 2016Article
- Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study.Schizophrenia research · 2015Article
- Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology.Evolution, medicine, and public health · 2015Review
- The role of GRIK4 gene in treatment-resistant depression.Genetics research · 2015Article
- Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study.Translational psychiatry · 2015Article
- GABAergic control of depression-related brain states.Advances in pharmacology (San Diego, Calif.) · 2015Article
- Transcriptome profiling of human hippocampus dentate gyrus granule cells in mental illness.Translational psychiatry · 2014Article
- Characterization of the early CNS stress biomarkers and profiles associated with neuropsychiatric diseases.Current genomics · 2012Article
- An epidemiologic and clinical overview of medical and psychopathological comorbidities in major psychoses.European archives of psychiatry and clinical neuroscience · 2011Article
- Sensorimotor transformation deficits for smooth pursuit in first-episode affective psychoses and schizophrenia.Biological psychiatry · 2010Article
- Chronic administration of atypical antipsychotics improves behavioral and synaptic defects of STOP null mice.Psychopharmacology · 2010Article
- Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.Biological psychiatry · 2009Article
- Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia.BMC medical genomics · 2009Article
- Genomic sister-disorders of neurodevelopment: an evolutionary approach.Evolutionary applications · 2009Article
- Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus.PloS one · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Depression is common in patients with schizophrenia and it is well established from family studies that rates of depression are increased among relatives of probands with schizophrenia, making it likely that the phenotypes described under the categories of affective and non-affective psychoses share some genetic risk factors. Family linkage studies have identified several chromosomal regions likely to contain risk genes for schizophrenia and bipolar disorder, suggesting common susceptibility loci. Candidate gene association studies have provided further evidence to suggest that some genes including two of the most studied candidates, Disrupted in Schizophrenia 1 (DISC1) and Neuregulin 1 (NRG1) may be involved in both types of psychosis. We have recently identified another strong candidate for a role in both schizophrenia and affective disorders, GRIK4 a glutamate receptor mapped to chromosome 11q23 [Glutamate Receptor, Ionotropic, Kainate, type 4]. This gene is disrupted by a translocation breakpoint in a patient with schizophrenia, and case control studies show significant association of GRIK4 with both schizophrenia and bipolar disorder. Identifying genes implicated in the psychoses may eventually provide the basis for classification based on biology rather than symptoms, and suggest novel treatment strategies for these complex brain disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.