ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2007
Alterations in the fibrinolytic cascade post-transplant: evidence of a bimodal expression pattern.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 7 citations in OpenAlex.
- What about cerebral venous sinus thrombosis? A series of three autopsy cases.Legal medicine (Tokyo, Japan) · 2022Article
- Consequences of Retained Defibrillator and Pacemaker Leads After Heart Transplantation-An Underrecognized Problem.Journal of cardiac failure · 2018Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChanges in the fibrinolytic system that occur after cardiac transplantation (CTx) and the factors that influence such changes have been poorly described, yet may be important in determining the varying morphologic features of transplant-related coronary artery disease (TxCAD).
methodsBaseline demographic as well as serial clinical information and plasma fibrinolytic levels were prospectively recorded pre-CTx and at multiple time-points post-CTx in 110 de novo cardiac transplant recipients.
resultsWe noted a biphasic change in fibrinolytic activity over the first year of CTx with an early immediate decline in plasminogen activator inhibitor-1 (PAI-1) activity (p > 0.001) matched with stable PAP (plasmin) activity corresponding to an "enhanced" fibrinolytic state early post-CTx. This was followed by a significant increase at 6 months (p = 0.004) and 1 year (p < 0.001) in PAI-1 activity concomitant with a significant decline in PAP after 3 months (p = 0.005 at 3 months, p < 0.001 at 6 months, p < 0.001 at 1 year) corresponding to an "impaired" fibrinolytic state late post-CTx.
conclusionThe biphasic nature of the fibrinolytic system observed herein may account for the varying morphologic features of TxCAD.
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