ArticleOsteoarthritis and cartilage2007
Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro.
Article in Osteoarthritis and cartilage, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Multi-functional Small Molecule for Regenerative Healing of Avascular Meniscus Tears: Modulation of Inflammation, Differentiation, and Multi-Tissue Crosstalk.Theranostics · 2026Article
- Epigenetic dynamics in meniscus cell migration and its zonal dependency in response to inflammatory conditions.APL bioengineering · 2025Article
- Electrospun Fiber Surface Roughness Modulates Human Monocyte-Derived Macrophage Phenotype.bioRxiv : the preprint server for biology · 2024Article
- Epigenetic Dynamics in Meniscus Cell Migration and its Zonal Dependency in Response to Inflammatory Conditions: Implications for Regeneration Strategies.bioRxiv : the preprint server for biology · 2024Article
- The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis.Frontiers in immunology · 2024Review
- Healthy but not osteoarthritic human meniscus-derived matrix scaffolds promote meniscus repair.Frontiers in bioengineering and biotechnology · 2024Article
- Transient inhibition of meniscus cell migration following acute inflammatory challenge.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Associations between meniscal tears and various degrees of osteoarthritis among dogs undergoing TPLO for cranial cruciate ligament rupture.BMC research notes · 2023Article
- The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.Current rheumatology reports · 2023Review
- Impediments to Meniscal Repair: Factors at Play Beyond Vascularity.Frontiers in bioengineering and biotechnology · 2022Article
- Advances in the Mechanisms Affecting Meniscal Avascular Zone Repair and Therapies.Frontiers in cell and developmental biology · 2021Review
- Post-Traumatic Osteoarthritis Assessment in Emerging and Advanced Pre-Clinical Meniscus Repair Strategies: A Review.Frontiers in bioengineering and biotechnology · 2021Review
- An animal model study on the gene expression profile of meniscal degeneration.Scientific reports · 2020Article
- Molecular biology of meniscus pathology: Lessons learned from translational studies and mouse models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Review
- Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair.International journal of molecular sciences · 2019Article
- Meniscus-Derived Matrix Scaffolds Promote the Integrative Repair of Meniscal Defects.Scientific reports · 2019Article
- Intra-Articular Cytokine Levels in Adolescent Patients after Anterior Cruciate Ligament Tear.Mediators of inflammation · 2018Article
- IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro.BMC musculoskeletal disorders · 2017Article
- Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis.International journal of molecular sciences · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveInjury or removal of the knee meniscus leads to progressive joint degeneration, and current surgical therapies for meniscal tears seek to maximally preserve meniscal structure and function. However, the factors that influence intrinsic repair of the meniscus are not well understood. The goal of this study was to investigate the capacity of meniscus tissue to repair a simulated defect in vitro and to examine the effect of pro-inflammatory cytokines on this process.
methodsCylindrical explants were harvested from the outer one-third of medial porcine menisci. To simulate a full-thickness defect, a central core was removed and reinserted immediately into the defect. Explants were cultured for 2, 4, or 6 weeks in serum-containing media in the presence or absence of interleukin-1 (IL-1) or tumor necrosis factor alpha (TNF-alpha), and meniscal repair was investigated using mechanical testing and fluorescence confocal microscopy.
resultsMeniscal lesions in untreated samples showed a significant capacity for intrinsic repair in vitro, with increasing cell accumulation and repair strength over time in culture. In the presence of IL-1 or TNF-alpha, no repair was observed despite the presence of abundant viable cells.
conclusionsThis study demonstrates that the meniscus exhibits an intrinsic repair response in vitro. However, the presence of pro-inflammatory cytokines completely inhibited repair. These findings suggest that increased levels of pro-inflammatory cytokines post-injury or under arthritic conditions may inhibit meniscal repair. Therefore, inhibition of these cytokines may provide a means of accelerating repair of damaged or injured menisci in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.