ArticleEpilepsy research2007
Optical suppression of seizure-like activity with an LED.
Article in Epilepsy research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin.Nature communications · 2021Article
- Selective Modification for Red-Shifted Excitability: A Small Change in Structure, a Huge Change in Photochemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Photolysis of Caged-GABA Rapidly Terminates SeizuresFrontiers in neurology · 2017Article
- Future of seizure prediction and intervention: closing the loop.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015Review
- Shining light on epilepsy: optical approaches for treating seizures.Epilepsy currents · 2013Article
- Toward new paradigms of seizure detection.Epilepsy & behavior : E&B · 2013Review
- Optical control of focal epilepsy in vivo with caged γ-aminobutyric acid.Annals of neurology · 2012Article
- Two-color, two-photon uncaging of glutamate and GABA.Nature methods · 2010Article
- Advances in the application of technology to epilepsy: the CIMIT/NIO Epilepsy Innovation Summit.Epilepsy & behavior : E&B · 2009Review
- Photorelease of GABA with Visible Light Using an Inorganic Caging Group.Frontiers in neural circuits · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The therapy of focal epilepsy remains unsatisfactory for as many as 25% of patients. We tested the hypothesis that an efficient, ultraviolet light emitting diode (UV LED), coupled with a newly developed "caged" gamma-aminobutyric acid (GABA), might be capable of terminating "ictal-like" events in cultured murine neurons. GABA was released from BC204, a recently described caged GABA, using a small, ultraviolet (UV) LED. Ictal-like events were provoked by removal of extracellular magnesium. In preliminary control experiments, the concentration of GABA released from our caged compound was dependent upon the strength and duration of the illumination, and readily achieved micromolar (microM) levels that are known to activate tonic, extrasynaptic GABA(A) receptors. Ultraviolet illumination had no effect when BC204 was not present in the perfusate and the currents produced by BC204 were eliminated by picrotoxin. Within a few seconds of UV illumination, BC204 rapidly terminated ictal-like events at low microM concentration. Uncaging of BC204 also blocked the elevation of intracellular calcium induced by seizure-like discharges in our cultures. While much more technical development is clearly required to extend our observations to a more intact preparation, these results suggest the intriguing possibility of constructing an implantable device to "optically suppress" focal human seizures under closed loop control.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.