ArticleGenome biology2007
Global analyses of mRNA translational control during early Drosophila embryogenesis.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
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- Analysis of mRNA Translation by Polysome Profiling.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Tissue-specific expression of ribosomal protein paralogue eRpL22-like in Drosophila melanogaster eye development.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Developmental regulation of canonical and small ORF translation from mRNAs.Genome biology · 2020Article
- Specialized eRpL22 paralogue-specific ribosomes regulate specific mRNA translation in spermatogenesis inMolecular biology of the cell · 2019Article
- Quantifying post-transcriptional regulation in the development of Drosophila melanogaster.Nature communications · 2018Article
- Translation and Translational Control in Dinoflagellates.Microorganisms · 2018Review
- Mechanism of translation control of the alternative Drosophila melanogaster Voltage Dependent Anion-selective Channel 1 mRNAs.Scientific reports · 2018Article
- Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs.Nucleic acids research · 2018Article
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- Ribosome reinitiation can explain length-dependent translation of messenger RNA.PLoS computational biology · 2017Article
- Ultra-deep sequencing of ribosome-associated poly-adenylated RNA in early Drosophila embryos reveals hundreds of conserved translated sORFs.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016Article
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- Proteomic analysis reveals APC-dependent post-translational modifications and identifies a novel regulator of β-catenin.Development (Cambridge, England) · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn many animals, the first few hours of life proceed with little or no transcription, and developmental regulation at these early stages is dependent on maternal cytoplasm rather than the zygotic nucleus. Translational control is critical for early Drosophila embryogenesis and is exerted mainly at the gene level. To understand post-transcriptional regulation during Drosophila early embryonic development, we used sucrose polysomal gradient analyses and GeneChip analysis to illustrate the translation profile of individual mRNAs.
resultsWe determined ribosomal density and ribosomal occupancy of over 10,000 transcripts during the first ten hours after egg laying.
conclusionWe report the extent and general nature of gene regulation at the translational level during early Drosophila embryogenesis on a genome-wide basis. The diversity of the translation profiles indicates multiple mechanisms modulating transcript-specific translation. Cluster analyses suggest that the genes involved in some biological processes are co-regulated at the translational level at certain developmental stages.
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