ArticleCritical care (London, England)2007
Premortem clinical diagnoses and postmortem autopsy findings: discrepancies in critically ill cancer patients.
Article in Critical care (London, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Clinical vs. autopsy diagnostic discrepancies in the intensive care unit: a systematic review and meta-analysis of autopsy series.Intensive care medicine · 2024Pooled it
- A systemic review of toxic death in clinical oncology trials: an Achilles' heel in safety reporting revisited.British journal of cancer · 2012Pooled it
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- Characteristics, Prognosis and Reasons for Opting-Out of Treatment in Patients with Untreated Pancreatic Cancer.Current oncology (Toronto, Ont.) · 2026Article
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- Large-vocabulary forensic pathological analyses via prototypical cross-modal contrastive learning.Nature communications · 2025Article
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- The discrepancy of antemortem clinical diagnosis and postmortem autopsy diagnosis of lung pathologies in under-five deaths and the reasons for discrepancies: a case series analysis.BMC pediatrics · 2024Article
- Comorbidity network analysis using graphical models for electronic health records.Frontiers in big data · 2023Article
- Thromboembolic and bleeding events in ICU patients with COVID-19: A nationwide, observational study.Acta anaesthesiologica Scandinavica · 2023Observational
- A Comprehensive Review of Pathological Examination in Forensic Medicine: Past, Present, and Future.Cureus · 2022Review
- The hospital autopsy: the importance in keeping autopsy an option.Autopsy & case reports · 2022Article
- A Visual and Comprehensive Review on COVID-19-Associated Pulmonary Aspergillosis (CAPA).Journal of fungi (Basel, Switzerland) · 2021Review
- Diagnostic discrepancies between antemortem clinical diagnosis and autopsy findings in pediatric cancer patients.Virchows Archiv : an international journal of pathology · 2021Article
- Frequency and Significance of Pathologic Pulmonary Findings in Postmortem Examinations-A Single Center Experience before COVID-19.Diagnostics (Basel, Switzerland) · 2021Article
- Can low autopsy rates be increased? Yes, we can! Should postmortem examinations in oncology be performed? Yes, we should! A postmortem analysis of oncological cases.Virchows Archiv : an international journal of pathology · 2021Article
- Autopsy among recipients of stem cell transplant for hematologic malignancies in the modern era.Bone marrow transplantation · 2021Article
- Cause of Death in Patients in Radiation Oncology.Frontiers in oncology · 2021Article
- Article
- Missed diagnosis and misdiagnosis of infectious diseases in hematopoietic cell transplant recipients: an autopsy study.Blood advances · 2019Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLimited data are available regarding the relationship of premortem clinical diagnoses and postmortem autopsy findings in cancer patients who die in an oncologic intensive care unit (ICU). The purposes of this study were to compare the premortem clinical and postmortem diagnoses of cancer patients who died in the ICU and to analyze any discrepancies between them.
methodsThis is a retrospective review of medical records and autopsy reports of all cancer patients who died in a medical-surgical ICU and had an autopsy performed between 1 January 1999 and 30 September 2005 at a tertiary care cancer center. Premortem clinical diagnoses were compared with the postmortem findings. Major missed diagnoses were identified and classified, according to the Goldman criteria, into class I and class II discrepancies.
resultsOf 658 deaths in the ICU during the study period, 86 (13%) autopsies were performed. Of the 86 patients, 22 (26%) had 25 major missed diagnoses, 12 (54%) patients had class I discrepancies, 7 (32%) had class II discrepancies, and 3 (14%) had both class I and class II discrepancies. Class I discrepancies were due to opportunistic infections (67%) and cardiac complications (33%), whereas class II discrepancies were due to cardiopulmonary complications (70%) and opportunistic infections (30%).
conclusionThere was a discrepancy rate of 26% between premortem clinical diagnoses and postmortem findings in cancer patients who died in a medical-surgical ICU at a tertiary care cancer center. Our findings underscore the need for enhanced surveillance, monitoring, and treatment of infections and cardiopulmonary disorders in critically ill cancer patients.
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