Trial reportAmerican journal of respiratory and critical care medicine2007
Persistent endothelial dysfunction in humans after diesel exhaust inhalation.
Trial report in American journal of respiratory and critical care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 165 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Diesel Exhaust Inhalation On Exercise Capacity In Patients With Stable Angina Pectoris
Effects of Ambient Air Pollution Exposure in Patients With Stable Angina Pectoris During Normal Daily Activities
The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin
Who cites it
165 citing papers in PubMed, 5 syntheses or guidelines pooled it, 400 citations in OpenAlex.
- Association between weather conditions and migraine: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Long-Term PMJournal of the American Heart Association · 2021Pooled it
- Short-term changes in ambient particulate matter and risk of stroke: a systematic review and meta-analysis.Journal of the American Heart Association · 2014Pooled it
- Systematic review and metaanalysis of air pollution exposure and risk of diabetes.European journal of epidemiology · 2014Pooled it
- Cardiovascular effects of sub-daily levels of ambient fine particles: a systematic review.Environmental health : a global access science source · 2010Pooled it
- First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses.Nature nanotechnology · 2024Trial
- Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study.Particle and fibre toxicology · 2021Trial
- The effects of facemasks on airway inflammation and endothelial dysfunction in healthy young adults: a double-blind, randomized, controlled crossover study.Particle and fibre toxicology · 2018Trial
- Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters.Particle and fibre toxicology · 2014Trial
- Respiratory effects of fine and ultrafine particles from indoor sources--a randomized sham-controlled exposure study of healthy volunteers.International journal of environmental research and public health · 2014Trial
- Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers.Environmental health : a global access science source · 2014Trial
- Effects of diesel exposure on lung function and inflammation biomarkers from airway and peripheral blood of healthy volunteers in a chamber study.Particle and fibre toxicology · 2013Trial
- Exposure to wood smoke increases arterial stiffness and decreases heart rate variability in humans.Particle and fibre toxicology · 2013Trial
- Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation.European heart journal · 2011Trial
- Acute decreases in proteasome pathway activity after inhalation of fresh diesel exhaust or secondary organic aerosol.Environmental health perspectives · 2011Trial
- Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions.Particle and fibre toxicology · 2010Trial
- Diesel exhaust inhalation elicits acute vasoconstriction in vivo.Environmental health perspectives · 2008Trial
- Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease.Environmental health perspectives · 2008Trial
- Joint association of cumulative workplace environmental exposures and shift work with long-term work-limiting health conditions: a prospective cohort study from the UK Biobank.BMJ public health · 2026Article
- Demonstration of particulate matter characterization from HVO-blended diesel using an integrated multi-instrument approach.Scientific reports · 2025Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
rationaleExposure to combustion-derived air pollution is associated with an early (1-2 h) and sustained (24 h) rise in cardiovascular morbidity and mortality. We have previously demonstrated that inhalation of diesel exhaust causes an immediate (within 2 h) impairment of vascular and endothelial function in humans.
objectivesTo investigate the vascular and systemic effects of diesel exhaust in humans 24 hours after inhalation.
methodsFifteen healthy men were exposed to diesel exhaust (particulate concentration, 300 microg/m(3)) or filtered air for 1 hour in a double-blind, randomized, crossover study. Twenty-four hours after exposure, bilateral forearm blood flow, and inflammatory and fibrinolytic markers were measured before and during unilateral intrabrachial bradykinin (100-1,000 pmol/min), acetylcholine (5-20 microg/min), sodium nitroprusside (2-8 microg/min), and verapamil (10-100 microg/min) infusions. MEASUREMENTS AND MAIN
resultsResting forearm blood flow, blood pressure, and basal fibrinolytic markers were similar 24 hours after either exposure. Diesel exhaust increased plasma cytokine concentrations (tumor necrosis factor-alpha and interleukin-6, p < 0.05 for both) but appeared to reduce acetylcholine (p = 0.01), and bradykinin (p = 0.08) induced forearm vasodilatation. In contrast, there were no differences in either endothelium-independent (sodium nitroprusside and verapamil) vasodilatation or bradykinin-induced acute plasma tissue plasminogen activator release.
conclusionsTwenty-four hours after diesel exposure, there is a selective and persistent impairment of endothelium-dependent vasodilatation that occurs in the presence of mild systemic inflammation. These findings suggest that combustion-derived air pollution may have important systemic and adverse vascular effects for at least 24 hours after exposure.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.