ArticleAnnals of the rheumatic diseases2007
Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis.
Article in Annals of the rheumatic diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 214 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
214 citing papers in PubMed, 2 syntheses or guidelines pooled it, 404 citations in OpenAlex.
- Fu's subcutaneous needling for knee osteoarthritis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis.Frontiers in physiology · 2021Pooled it
- Trial
- Efficacy of combination of meloxicam and pregabalin for pain in knee osteoarthritis.Yonsei medical journal · 2013Trial
- Emerging therapies for knee osteoarthritis.Nature reviews. Rheumatology · 2026Review
- Sensing the skeleton: sensorineural regulation in bone.Nature reviews. Neuroscience · 2026Review
- Genicular Artery Embolization (GAE) for the Treatment of Advanced Knee Osteoarthritis in Selected Nonoperative Patients: A Pilot Study at 6 Months Follow-Up.Journal of clinical medicine · 2026Article
- Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling.Bone research · 2026Article
- Review
- Exosomes from mesenchymal stem/stromal cells and their therapeutic role in osteoarthritic pain.Journal of experimental orthopaedics · 2026Article
- Joint capsule pathology as a contributor to pain in hallux valgus: a histological study.Scientific reports · 2026Article
- The complexity of pain in osteoarthritis.Nature reviews. Rheumatology · 2026Review
- Systemic implications of osteoarthritis: from local degeneration to systemic metabolic Dysregulation.Journal of translational medicine · 2026Review
- Advanced tissue clearing and three-dimensional imaging approaches to visualize neural innervation in the rat knee joints.Npj imaging · 2026Article
- Three-dimensional visualization of nerves in bones of the human hand in osteoarthritis.JBMR plus · 2026Article
- Disruption of the microenvironmental ecosystem in subchondral bone marrow lesions: Roles in osteoarthritis pathophysiology, pain and progression.Osteoarthritis imaging · 2026Article
- Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.Journal of biological engineering · 2026Article
- Human Knee as an Organ: Joint Tissue Collection, Processing, and Scoring for Multimodal Analyses.Laboratory investigation; a journal of technical methods and pathology · 2026Review
- Transcriptomics in the Study of Bone and Cartilage.Current osteoporosis reports · 2026Review
- Mechanism driven adaptation of smart hydrogels to the osteoarthritis pathological microenvironment.Frontiers in bioengineering and biotechnology · 2026Review
154 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNormal adult articular cartilage is thought to be avascular and aneural.
objectiveTo describe neurovascular structures at the osteochondral junction and in osteophytes in tibiofemoral osteoarthritis (OA) displaying a range of severity of cartilage changes.
methodsArticular surfaces were obtained from 40 patients at total knee joint replacement surgery for tibiofemoral OA (TKR) and seven patients post mortem (PM). Antibodies directed against CD34 (vascular endothelium), protein gene product 9.5 (pan-neuronal marker), substance P and calcitonin gene-related peptide (sensory nerves) and C-flanking peptide of neuropeptide Y (sympathetic nerves) were used to localise blood vessels and nerves by immunohistochemistry. Severity of OA cartilage changes was graded histologically.
resultsTKR and PM samples displayed a range of OA cartilage changes including tidemark breaching by vascular channels. Sympathetic and sensory nerves were both present within vascular channels in the articular cartilage, in both mild and severe OA. Perivascular and free nerve fibres, and nerve trunks were observed within the subchondral bone marrow and within the marrow cavities of osteophytes. Sensory and sympathetic nerves displayed similar distributions in each region studied.
conclusionVascularisation and the associated innervation of articular cartilage may contribute to tibiofemoral pain in OA across a wide range of structural disease severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.