ArticleThe Journal of physiology2007
Control of basal extracellular adenosine concentration in rat cerebellum.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 65 citations in OpenAlex.
- NADInternational journal of molecular sciences · 2026Article
- Interplay between metabotropic glutamate type 4 and adenosine type 1 receptors modulate synaptic transmission in the cerebellar cortex.Frontiers in pharmacology · 2024Article
- ATP and adenosine-Two players in the control of seizures and epilepsy development.Progress in neurobiology · 2021Review
- Metabolic Aspects of Adenosine Functions in the Brain.Frontiers in pharmacology · 2021Review
- Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus.British journal of pharmacology · 2018Article
- Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- ATP release during cell swelling activates a CaScientific reports · 2017Article
- Reducing Extracellular CaFrontiers in neural circuits · 2017Article
- Ethanol-Induced Cerebellar Ataxia: Cellular and Molecular Mechanisms.Cerebellum (London, England) · 2015Article
- Cell type-specific effects of adenosine on cortical neurons.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Localized adenosine signaling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities.Journal of neurophysiology · 2015Article
- Presynaptic adenosine A₁ receptors modulate excitatory transmission in the rat basolateral amygdala.Neuropharmacology · 2014Article
- Expression of nucleoside transporter in freshly isolated neurons and astrocytes from mouse brain.Neurochemical research · 2013Article
- Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus.The Journal of physiology · 2013Article
- The mechanism of electrically stimulated adenosine release varies by brain region.Purinergic signalling · 2013Article
- K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.British journal of pharmacology · 2012Article
- Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons.Journal of neurophysiology · 2012Article
- Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Purinergic modulation of granule cells.Cerebellum (London, England) · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
To re-examine how the basal extracellular concentration of adenosine is regulated in acutely isolated cerebellar slices we have combined electrophysiological and microelectrode biosensor measurements. In almost all cases, synaptic transmission was tonically inhibited by adenosine acting via A1 receptors. By contrast, in most slices, the biosensors did not measure an adenosine tone but did record a spatially non-uniform extracellular tone of the downstream metabolites (inosine and hypoxanthine). Most of the extracellular hypoxanthine arose from the metabolism of inosine by ecto-purine nucleoside phosphorylase (PNP). Adenosine kinase was the major determinant of adenosine levels, as its inhibition increased both adenosine concentration and A1 receptor-mediated synaptic inhibition. Breakdown of adenosine by adenosine deaminase was the major source of the inosine/hypoxanthine tone. However adenosine deaminase played a minor role in determining the level of adenosine at synapses, suggesting a distal location. Blockade of adenosine transport (by NBTI/dipyridamole) had inconsistent effects on basal levels of adenosine and synaptic transmission. Unexpectedly, application of NBTI/dipyridamole prevented the efflux of adenosine resulting from block of adenosine kinase at only a subset of synapses. We conclude that there is spatial variation in the functional expression of NBTI/dipyridamole-sensitive transporters. The increased spatial and temporal resolution of the purine biosensor measurements has revealed the complexity of the control of adenosine and purine tone in the cerebellum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.